{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:36:16Z","timestamp":1789634176743,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T00:00:00Z","timestamp":1255910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The vestibular portion of the inner ear, the three semicircular canals and their sensory cristae, is responsible for detecting angular head movements. It was proposed that sensory cristae induce formation of their non\u2010sensory components, the semicircular canals. Here, we analyzed the inner ears of <jats:italic>Foxg1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mouse mutants, which display vestibular defects that are in conflict with the above model. In <jats:italic>Foxg1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> ears, the lateral canal is present without the lateral ampulla, which houses the lateral crista. Our gene expression analyses indicate that at the time when canal specification is thought to occur, the prospective lateral crista is present, which could have induced lateral canal formation prior to its demise. Our genetic fate\u2010mapping analyses indicate an improper separation between anterior and lateral cristae in <jats:italic>Foxg1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mutants. Our data further suggest that a function of Foxg1 in the inner ear is to restrict sensory fate. Developmental Dynamics 238:2725\u20132734, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22111","type":"journal-article","created":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T14:46:09Z","timestamp":1255963569000},"page":"2725-2734","source":"Crossref","is-referenced-by-count":54,"title":["<i>Foxg1<\/i> is required for proper separation and formation of sensory cristae during inner ear development"],"prefix":"10.1002","volume":"238","author":[{"given":"Chan Ho","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Simeone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eseng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris 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