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The developmental principles regulating expression of specific gene subsets in individual cell types are not fully understood. Here we define the <jats:italic>cis<\/jats:italic>\u2010regulatory mechanisms driving expression of cell\u2010selective and broadly expressed genes in vivo in the AWB olfactory neuron subtype in <jats:italic>C. elegans<\/jats:italic>. We identify an element that is necessary to drive expression of neuron\u2010selective chemoreceptor genes in the AWB neurons, and show that this element functions in a context\u2010dependent manner. We find that the expression of broadly expressed sensory neuronal genes in the AWB neurons is regulated by diverse <jats:italic>cis<\/jats:italic>\u2010 and <jats:italic>trans<\/jats:italic>\u2010regulatory mechanisms that act partly in parallel to the pathways governing expression of AWB\u2010selective genes. We further demonstrate that <jats:italic>cis<\/jats:italic>\u2010acting mechanisms driving gene expression in the AWB neurons appear to have diverged in related nematode species. Our results provide insights into the <jats:italic>cis<\/jats:italic>\u2010regulatory logic driving cell\u2010specific gene expression, and suggest that variations in this logic contribute to the generation of functional diversity. Developmental Dynamics 238:3080\u20133092, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22147","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T01:01:37Z","timestamp":1258592497000},"page":"3080-3092","source":"Crossref","is-referenced-by-count":17,"title":["<i>Cis<\/i>\u2010regulatory mechanisms of gene expression in an olfactory neuron type in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1002","volume":"238","author":[{"given":"Eva B.","family":"Nokes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M.","family":"Van Der 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