{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:12:38Z","timestamp":1760404358999,"version":"build-2065373602"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ventral urogenital sinus (UGS) of control male mice has two rows of 3\u20134 prostatic buds at birth, but how androgens regulate ventral bud (VB) number and patterning is unclear. VBs in both sexes appeared to be a mixture of prostatic and urethral buds. UGSs from <jats:italic>Tfm<\/jats:italic> male and antiandrogen (flutamide)\u2010exposed mice had small VBs, suggesting that initiation of some VBs is androgen independent. <jats:italic>Tfm<\/jats:italic> male mice are widely considered completely androgen insensitive yet their UGSs were 5\u03b1\u2010dihydrotestosterone (DHT)\u2010 responsive. VBs (6\u20138) were generally distributed bimodally on the left\u2010right axis at both minimal and normal male androgen signaling. Yet control females and DHT\u2010exposed <jats:italic>Tfm<\/jats:italic> males had 13\u201314 VBs, whose left\u2010right distribution was fairly uniform. These results suggest that VB number and distribution respond biphasically as androgen signaling increases from minimal, and that androgens regulate bud specification. Complete VB agenesis by the selective budding inhibitor 2,3,7,8\u2010tetrachlorodibenzo\u2010<jats:italic>p<\/jats:italic>\u2010dioxin (TCDD) required high androgen signaling. Developmental Dynamics 239:373\u2013385, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22169","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T17:23:53Z","timestamp":1259169833000},"page":"373-385","source":"Crossref","is-referenced-by-count":24,"title":["Androgenic regulation of ventral epithelial bud number and pattern in mouse urogenital sinus"],"prefix":"10.1002","volume":"239","author":[{"given":"Sarah H.","family":"Allgeier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien\u2010Min","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad M.","family":"Vezina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa L.","family":"Abler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg238"},{"key":"e_1_2_6_3_1","unstructured":"AllgeierSH.2007.Dioxin and signaling pathways in prostate development. 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