{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:24:17Z","timestamp":1789921457932,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T00:00:00Z","timestamp":1260835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Iroquois homeobox\u2010like 1<\/jats:italic> (<jats:italic>irxl1<\/jats:italic>) is a novel member of the TALE superfamily of homeobox genes that is most closely related to the <jats:italic>Iroquois<\/jats:italic> class. We have identified the zebrafish <jats:italic>irxl1<\/jats:italic> gene and characterized its structure. The protein contains a homeodomain that shares 100% sequence identity with other vertebrate orthologs. During embryogenesis, <jats:italic>irxl1<\/jats:italic> is expressed from 18 hours postfertilization onward and prominent expression is detected in the pharyngeal arches. Knockdown of <jats:italic>irxl1<\/jats:italic> by morpholinos results in malformed brain and arch structures, which can be partially rescued by cRNA injection. The heads of the morphants become small and flat, and extensions along the anterior\u2013posterior\/dorso\u2013ventral axes are reduced without affecting regional specification. Loss of irxl1 function also causes deficit in neural crest cells which consequently results in partial loss of craniofacial muscles and severe deformation of arch cartilages. These observations suggest that irxl1 may regulate factors involved in brain and pharyngeal arch development. Developmental Dynamics 239:639\u2013650, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22187","type":"journal-article","created":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T11:55:17Z","timestamp":1260878117000},"page":"639-650","source":"Crossref","is-referenced-by-count":13,"title":["The zebrafish homeobox gene irxl1 is required for brain and pharyngeal arch morphogenesis"],"prefix":"10.1002","volume":"239","author":[{"given":"Han\u2010Ni","family":"Chuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao\u2010Yun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang\u2010Ming","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh\u2010Wen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01616"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20671"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21873"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.15.3258"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5405.1161"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(02)00628-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.22.4933"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.15.2847"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-004-0402-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-002-0217-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.1038"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(96)00616-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-004-0401-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.63.070194.002415"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.22.2935"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(02)00317-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10980"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2000.1147"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2001.19910105.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90290-9"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20765"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0341"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(96)00577-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.08.042"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2005.11.012"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-006-0023-0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199910)216:2<96::AID-DVDY2>3.0.CO;2-6"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.144100"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030078"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.123.1.329"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2006.05.007"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.514"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2005.06.007"},{"key":"e_1_2_6_36_1","first-page":"443","article-title":"In silico characterization of an Iroquois family\u2010related homeodomain protein","volume":"16","author":"Weinmann A","year":"2005","journal-title":"Int J Mol Med"},{"key":"e_1_2_6_37_1","volume-title":"The zebrafish book. 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