{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:22:17Z","timestamp":1774876937008,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T00:00:00Z","timestamp":1262908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mammalian organ of Corti of the inner ear is a highly sophisticated sensory end organ responsible for detecting sound. Noggin is a secreted glycoprotein, which antagonizes bone morphogenetic proteins 2 and 4 (Bmp2 and Bmp4). The lack of this antagonist causes increased rows of inner and outer hair cells in the organ of Corti. In mice, <jats:italic>Bmp2<\/jats:italic> is expressed transiently in nascent cochlear hair cells. To investigate whether Noggin normally modulates the levels of <jats:italic>Bmp2<\/jats:italic> for hair cell formation, we deleted <jats:italic>Bmp2<\/jats:italic> in the cochlear hair cells using two <jats:italic>cre<\/jats:italic> strains, <jats:italic>Foxg1<\/jats:italic><jats:sup><jats:italic>cre<\/jats:italic>\/+<\/jats:sup> and <jats:italic>Gfi1<\/jats:italic><jats:sup><jats:italic>cre<\/jats:italic>\/+<\/jats:sup>. <jats:italic>Bmp2<\/jats:italic> conditional knockout cochleae generated using these two <jats:italic>cre<\/jats:italic> strains show normal hair cells. Furthermore, <jats:italic>Gfi1<\/jats:italic><jats:sup><jats:italic>cre<\/jats:italic>\/+<\/jats:sup>;<jats:italic>Bmp2<\/jats:italic><jats:sup><jats:italic>lox<\/jats:italic>\/\u2212<\/jats:sup> mice are viable and have largely normal hearing. The combined results of <jats:italic>Noggin<\/jats:italic> and <jats:italic>Bmp2<\/jats:italic> mutants suggest that Noggin is likely to regulate other Bmps in the cochlea such as Bmp4. Developmental Dynamics 239:505\u2013513, 2010. 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