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As the lipid storage field has recently been reviewed, in this minireview we (1) discuss some recent studies revealing important physiological roles for lipases in mobilizing lipid reserves, (2) describe various pathways of lipid transport, with a particular focus on the roles of lipoproteins, (3) debate the utility of using <jats:italic>C. elegans<\/jats:italic> as a model for human dyslipidemias that impinge on atherosclerosis, and (4) describe several systems where lipids affect signaling, highlighting the particular properties of lipids as information\u2010carrying molecules. We conclude that the study of lipid biology in <jats:italic>C. elegans<\/jats:italic> exemplifies the advantages afforded by a whole\u2010animal model system where interactions between tissues and organs, and functions such as nutrient absorption, distribution, and storage, as well as reproduction can all be studied simultaneously. Developmental Dynamics 239:1365\u20131377, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22234","type":"journal-article","created":{"date-parts":[[2010,2,11]],"date-time":"2010-02-11T10:51:51Z","timestamp":1265885511000},"page":"1365-1377","source":"Crossref","is-referenced-by-count":28,"title":["Lipid transport and signaling in <i>Caenorhabditis 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