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In this study, we show that procollagen IIA (IIA), an isoform of the cartilage extracellular matrix protein encoded by an alternatively spliced transcript of <jats:italic>Col2a1<\/jats:italic>, is expressed in the prechordal plate and the anterior definitive endoderm. In the absence of IIA activity, the null mutants displayed a partially penetrant phenotype of loss of head tissues, holoprosencephaly, and loss of mid\u2010facial structures, which is associated with reduced sonic hedgehog (<jats:italic>Shh<\/jats:italic>) expression in the prechordal mesoderm. Genetic interaction studies reveal that IIA function in forebrain and face development does not involve bone morphogenetic protein receptor 1A (BMPR1A)\u2010 or NODAL\u2010mediated signaling activity. Developmental Dynamics 239:2319\u20132329. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22366","type":"journal-article","created":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T07:12:44Z","timestamp":1283497964000},"page":"2319-2329","source":"Crossref","is-referenced-by-count":29,"title":["Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain"],"prefix":"10.1002","volume":"239","author":[{"given":"Alan W.L.","family":"Leung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Y.Y.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick 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