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Expression of homeobox genes, potential mediators of tissue\u2010specific morphological development, was assessed. Twenty homeobox genes were identified as either tissue\u2010enriched, developmentally regulated, or both. Additionally, ontology analysis demonstrated cell adhesion to be highly regulated along the length of the reproductive tract. Regulators of cell adhesion with variable expression between the three tissues were identified including <jats:italic>Alcam<\/jats:italic>, various cadherins, and multiple integrins. Immunofluorescence localization of the cell adhesion regulators POSTN and CDH2 demonstrated cell adhesion in the epithelium and mesenchyme of the epididymis may change throughout development. These results suggest cell adhesion may be modulated in a tissue\u2010specific manner, playing an important role in establishing each tissue's final morphology. 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