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Here we use two transgenic mouse models of Apert syndrome, <jats:italic>Fgfr2<\/jats:italic><jats:sup>+\/<jats:italic>S252W<\/jats:italic><\/jats:sup> and <jats:italic>Fgfr2<\/jats:italic><jats:sup>+\/<jats:italic>P253R<\/jats:italic><\/jats:sup>, to explore variation in cranial phenotypes in newborn (P0) mice. Results show that the facial skeleton is the most affected region of the cranium. Coronal suture patency shows marked variation that is not strongly correlated with skull dysmorphology. The craniofacial effects of the FGFR2 mutations are similar, but <jats:italic>Fgfr2<\/jats:italic><jats:sup>+\/<jats:italic>S252W<\/jats:italic><\/jats:sup> mutant mice display significantly more severe dysmorphology localized to the posterior palate. Our results demonstrate that coronal suture closure is neither the primary nor the sole locus of skull dysmorphology in these mouse models for Apert syndrome, but that the face is also primarily affected. Developmental Dynamics 239:3058\u20133071, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22414","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T10:03:47Z","timestamp":1284458627000},"page":"3058-3071","source":"Crossref","is-referenced-by-count":63,"title":["Beyond the closed suture in apert syndrome mouse models: Evidence of primary effects of FGFR2 signaling on facial shape at birth"],"prefix":"10.1002","volume":"239","author":[{"given":"Neus","family":"Mart\u00ednez\u2010Abad\u00edas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Percival","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Aldridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl 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