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Our results demonstrate that FGF8 induces <jats:italic>Tbx22<\/jats:italic> in the early face while BMP4 represses and thus restricts its expression. This regulation is conserved between chicken and mouse, although the <jats:italic>Tbx22<\/jats:italic>\u2010expression patterns differ considerably between these two species. We suggest that these species\u2010specific differences may result at least in part from differences in the spatiotemporal patterns of BMP activity, but we exclude a direct repression of <jats:italic>Tbx22<\/jats:italic> by the BMP\u2010inducible transcriptional repressor MSX1. Together these findings help to integrate <jats:italic>Tbx22<\/jats:italic> into the molecular network of factors regulating facial development. Developmental Dynamics 239:2860\u20132874, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22421","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T16:05:18Z","timestamp":1284566718000},"page":"2860-2874","source":"Crossref","is-referenced-by-count":29,"title":["Regulation of <i>Tbx22<\/i> during facial and palatal 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