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Here, we present evidence that <jats:italic>cdh6<\/jats:italic> has specific functions during cranial and lateral line ganglia and nerve development. We analyzed the consequences of <jats:italic>cdh6<\/jats:italic> loss\u2010of\u2010function on cranial ganglion and nerve differentiation in zebrafish embryos. Embryos injected with zebrafish <jats:italic>cdh6<\/jats:italic> specific antisense morpholino oligonucleotides (MOs, which suppress gene expression during development; <jats:italic>cdh6<\/jats:italic> morphant embryos) displayed a specific phenotype, including (i) altered shape and reduced development of a subset of the cranial and lateral line ganglia (e.g., the statoacoustic ganglion and vagal ganglion) and (ii) cranial nerves were abnormally formed. These data illustrate an important role for <jats:italic>cdh6<\/jats:italic> in the formation of cranial ganglia and their nerves. 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