{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:56:14Z","timestamp":1786535774593,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T00:00:00Z","timestamp":1310601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The synuclein family consists of three small intracellular proteins mainly expressed in neural tissues, and has been associated with human neurodegenerative diseases. We have examined the spatial and temporal expression patterns of three synuclein genes during embryogenesis of <jats:italic>Xenopus laevis<\/jats:italic>. The <jats:italic>Xenopus<\/jats:italic> synucleins were firstly expressed in the developing nervous system at the tail bud stages. At tadpole stages, <jats:italic>Xenopus snca<\/jats:italic> was expressed in the brain, branchial arch and somite, and <jats:italic>sncbb<\/jats:italic> signals were detected in entire brain and spinal cord. However, <jats:italic>sncg<\/jats:italic> was only expressed in the peripheral nervous system including trigeminal nerve and dorsal root ganglion. RT\u2010PCR indicated that expression of synucleins was up\u2010regulated at the end of neurulation, and then maintained at later examined stages. Our study provides the spatiotemporal expression patterns of the synuclein family genes in <jats:italic>Xenopus<\/jats:italic> embryos, and forms a basis for further functional analysis of synucleins. Developmental Dynamics 240:2028\u20132033, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22693","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T15:59:20Z","timestamp":1310659160000},"page":"2028-2033","source":"Crossref","is-referenced-by-count":16,"title":["Characterization of three synuclein genes in <i>Xenopus laevis<\/i>"],"prefix":"10.1002","volume":"240","author":[{"given":"Chengdong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wood Yee","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun On","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Grunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80886-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195227"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-20-08797.2002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406283101"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17103-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.74.082803.133400"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.16.9443"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087753"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1101"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13450"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20036"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005005107"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(08)60307-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313784200"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00462-7"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.4992\/jjpsy.75.353"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.092984rk"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.062236rm"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-09-03214.2000"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.12.023"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.22.8233-8245.2003"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp090"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2045"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100061"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090278"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21569"},{"key":"e_1_2_5_29_1","first-page":"920","article-title":"Stage\u2010specific expression of breast cancer\u2010specific gene gamma\u2010synuclein","volume":"12","author":"Wu K","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10795"},{"key":"e_1_2_5_31_1","first-page":"817","article-title":"Isolation and characterization of a Xenopus gene (XMLP) encoding a MARCKS\u2010like protein","volume":"45","author":"Zhao H","year":"2001","journal-title":"Int J Dev Biol"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.22693","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.22693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T18:24:21Z","timestamp":1760379861000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.22693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,14]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1002\/dvdy.22693"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.22693","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,14]]}}}