{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:47:48Z","timestamp":1775000868351,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T00:00:00Z","timestamp":1327968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Background<\/jats:styled-content>: Disorders of the urinary tract represent a major cause of morbidity and impaired quality of life. To better understand the morphological events responsible for normal urinary tract development, we performed 3\u2010D reconstructive analysis of developing mouse bladders in control, <jats:italic>mgb\u2212\/\u2212<\/jats:italic>, and <jats:italic>Fgfr2<jats:sup>Mes\u2212\/\u2212<\/jats:sup><\/jats:italic> mice. <jats:styled-content>Results<\/jats:styled-content>: Detrusor smooth muscle differentiation initiated in the bladder dome and progressed caudally with the leading edge extending down the right posterior surface of the bladder. Gender\u2010specific differences in detrusor smooth muscle development were observed during early embryonic development. Bladder trigone morphology transitioned from an isosceles to equilateral triangle during development due to the preferential lengthening of the urethra to ureter distance. The primary defect observed in <jats:italic>mgb\u2212\/\u2212<\/jats:italic> bladders was a significant reduction in detrusor smooth muscle differentiation throughout development. Deviations from normal trigone morphology correlated best with VUR development in <jats:italic>Fgfr2<jats:sup>Mes\u2212\/\u2212<\/jats:sup><\/jats:italic> mice, while alterations in intravesicular tunnel length did not. <jats:styled-content>Conclusions<\/jats:styled-content>: Multivariate morphometric analysis provides a powerful tool to quantify and assess urinary tract development. Developmental Dynamics 241:522\u2013533, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.23744","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T10:11:41Z","timestamp":1326967901000},"page":"522-533","source":"Crossref","is-referenced-by-count":9,"title":["3\u2010dimensional morphometric analysis of murine bladder development and dysmorphogenesis"],"prefix":"10.1002","volume":"241","author":[{"given":"Ashley","family":"Carpenter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Paulus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlton M.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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