{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:31:17Z","timestamp":1767857477066,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T00:00:00Z","timestamp":1340323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Hes1<\/jats:italic> gene represses the expression of proneural basic helix\u2013loop\u2013helix (bHLH) factor Mash1, which is essential for the differentiation of the sympathetic ganglia and carotid body glomus cells. The sympathetic ganglia, carotid body, and common carotid artery in Wnt1\u2010Cre\/R26R double transgenic mice were intensely labeled by X\u2010gal staining, i.e., the neural crest origin. The deficiency of <jats:italic>Hes1<\/jats:italic> caused severe hypoplasia of the superior cervical ganglion (SCG). At embryonic day (E) 17.5\u2013E18.5, the volume of the SCG in <jats:italic>Hes1<\/jats:italic> null mutants was reduced to 26.4% of the value in wild\u2010type mice. In 4 of 30 cases (13.3%), the common carotid artery derived from the third arch artery was absent in the null mutants, and the carotid body was not formed. When the common carotid artery was retained, the organ grew in the wall of the third arch artery and glomus cell precursors were provided from the SCG in the null mutants as well as in wild\u2010types. However, the volume of carotid body in the null mutants was only 52.5% of the value in wild\u2010types at E17.5\u2013E18.5. These results suggest that Hes1 plays a critical role in regulating the development of neural crest derivatives in the mouse cervical region. Developmental Dynamics 241:1289\u20131300, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.23819","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T12:07:09Z","timestamp":1339416429000},"page":"1289-1300","source":"Crossref","is-referenced-by-count":18,"title":["Hes1 is required for the development of the superior cervical ganglion of sympathetic trunk and the carotid 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