{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T16:41:42Z","timestamp":1760373702717,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p><jats:styled-content>Background:<\/jats:styled-content> The zebrafish pineal gland (epiphysis) is a site of melatonin production, contains photoreceptor cells, and functions as a circadian clock pacemaker. Since it is located on the surface of the forebrain, it is accessible for manipulation and, therefore, is a useful model system to analyze pineal gland function and development. We previously analyzed the pineal transcriptome during development and showed that many genes exhibit a highly dynamic expression pattern in the pineal gland. <jats:styled-content>Results:<\/jats:styled-content> Among genes preferentially expressed in the zebrafish pineal gland, we identified a tissue\u2010specific form of the <jats:italic>unc119<\/jats:italic> gene family, <jats:italic>unc119c<\/jats:italic>, which is highly preferentially expressed in the pineal gland during day and night at all stages examined from embryo to adult. When expression of <jats:italic>unc119c<\/jats:italic> was inhibited, the formation of the habenular commissure (HC) was specifically compromised. The Unc119c interacting factors Arl3l1 and Arl3l2 as well as Wnt4a also proved indispensible for HC formation. <jats:styled-content>Conclusions:<\/jats:styled-content> We suggest that Unc119c, together with Arl3l1\/2, plays an important role in modulating Wnt4a production and secretion during HC formation in the forebrain of the zebrafish embryo. <jats:italic>Developmental Dynamics 242:1033\u20131042, 2013<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.23994","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T02:14:50Z","timestamp":1370830490000},"page":"1033-1042","source":"Crossref","is-referenced-by-count":6,"title":["Habenular commissure formation in zebrafish is regulated by the pineal gland\u2013specific gene <i>unc119c<\/i>"],"prefix":"10.1002","volume":"242","author":[{"given":"Reiko","family":"Toyama","sequence":"first","affiliation":[{"name":"Program in Genomics of Development NICHD NIH Bethesda 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