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The molecular basis of intramembranous bone regeneration has been interrogated using rodent models of most of these conditions. These studies reveal that signaling pathways such as Wnt, TGF\u03b2\/BMP, FGF, VEGF, and Notch are invoked, reminiscent of embryonic development of membranous bone. Discoveries of several skeletal stem cell\/progenitor populations using mouse genetic models also reveal the potential sources of postnatal intramembranous bone regeneration. The purpose of this review is to compare the underlying molecular signals and progenitor cells that characterize embryonic development of membranous bone and postnatal intramembranous bone regeneration.<\/jats:p>","DOI":"10.1002\/dvdy.240","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T23:00:19Z","timestamp":1598569219000},"page":"377-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["How faithfully does intramembranous bone regeneration recapitulate embryonic skeletal development?"],"prefix":"10.1002","volume":"250","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7305-7946","authenticated-orcid":false,"given":"Frank C.","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Cell &amp; Molecular Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-3862","authenticated-orcid":false,"given":"D. 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