{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:10:30Z","timestamp":1760487030681,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,25]],"date-time":"2013-12-25T00:00:00Z","timestamp":1387929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"crossref","award":["250433","111902"],"award-info":[{"award-number":["250433","111902"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ryerson Deans Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p><jats:styled-content><jats:bold>Background:<\/jats:bold><\/jats:styled-content> UNC\u20106 and SLT\u20101 guide the migrations of the ventrally directed processes of the AVM and PVM touch receptor neurons and UNC\u20106 guides the axons of the DA and DB classes of motor neurons in <jats:italic>C. elegans<\/jats:italic>. The UNC\u20106 receptors are UNC\u20105 and UNC\u201040. The axon outgrowth defects of a subset of the DB motor neurons in the absence of UNC\u20105 are enhanced by mutations in <jats:italic>enu\u20103<\/jats:italic>. <jats:styled-content><jats:bold>Results:<\/jats:bold><\/jats:styled-content> An <jats:italic>enu\u20103<\/jats:italic> mutation enhances defects in ventral guidance of the processes of the AVM and PVM touch receptor neurons, the dorsal guidance of the distal tip cell and causes additional architectural defects in axons in <jats:italic>unc\u201040<\/jats:italic> mutant strains in an UNC\u20106 dependent manner. These observations suggest that ENU\u20103 and UNC\u201040 function in parallel pathways dependent on UNC\u20106. ENU\u20103 depends on the presence of UNC\u201040 for its full effect on motor neuron axon outgrowth. <jats:styled-content><jats:bold>Conclusions:<\/jats:bold><\/jats:styled-content> ENU\u20103 works in an UNC\u20106 dependent pathway parallel to UNC\u201040 in ventral guidance of AVM and PVM and in dorsal guidance of the distal tip cells. Motor neuron axon outgrowth defects are caused by the presence of UNC\u201040 and the absence of functional UNC\u20105 or UNC\u20106 and defects are enhanced by the absence of functional ENU\u20103. <jats:italic>Developmental Dynamics 243:459\u2013467, 2014<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24063","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:38:51Z","timestamp":1381531131000},"page":"459-467","source":"Crossref","is-referenced-by-count":3,"title":["ENU\u20103 functions in an UNC\u20106\/netrin dependent pathway parallel to UNC\u201040\/DCC\/frazzled for outgrowth and guidance of the touch receptor neurons in <i>C. elegans<\/i>"],"prefix":"10.1002","volume":"243","author":[{"given":"Callista","family":"Yee","sequence":"first","affiliation":[{"name":"Graduate Program in Molecular Science Ryerson University Toronto Ontario Canada M5B 2K3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Florica","sequence":"additional","affiliation":[{"name":"Graduate Program in Molecular Science Ryerson University Toronto Ontario Canada M5B 2K3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Fillingham","sequence":"additional","affiliation":[{"name":"Graduate Program in Molecular Science Ryerson University Toronto Ontario Canada M5B 2K3"},{"name":"Department of Chemistry and Biology Ryerson University Toronto Ontario Canada"},{"name":"Graduate Program in Biology York University Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie T.","family":"Killeen","sequence":"additional","affiliation":[{"name":"Graduate Program in Molecular Science Ryerson University Toronto Ontario Canada M5B 2K3"},{"name":"Department of Chemistry and Biology Ryerson University Toronto Ontario Canada"},{"name":"Graduate Program in Biology York University Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1666"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81337-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90459-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-04-00956.1985"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096983"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-76715-4_9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.12.048"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/164.4.1355"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90083-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5377.706"},{"key":"e_1_2_6_13_1","first-page":"a001800","article-title":"The growth cone cytoskeleton in axon outgrowth and guidance","volume":"1","author":"Dent EW","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"e_1_2_6_14_1","unstructured":"DurbinRM.1987.Studies on the development and organisation of the nervous system of Caenorhabditis elegans. 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