{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:11:29Z","timestamp":1772500289630,"version":"3.50.1"},"reference-count":77,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p><jats:styled-content><jats:bold>Background<\/jats:bold>:<\/jats:styled-content> The Slitrk family of leucine\u2010rich repeat (LRR) transmembrane proteins bears structural similarity to the Slits and the Trk receptor families, which exert well\u2010established roles in directing nervous system development. Slitrks are less well understood, although they are highly expressed in the developing vertebrate nervous system. Moreover, <jats:italic>slitrk<\/jats:italic> variants are associated with several sensory and neuropsychiatric disorders, including myopia, deafness, obsessive\u2010compulsive disorder (OCD), schizophrenia, and Tourette syndrome. Loss\u2010of\u2010function studies in mice show that Slitrks modulate neurite outgrowth and inhibitory synapse formation, although the molecular mechanisms of Slitrk function remain poorly characterized. <jats:styled-content><jats:bold>Results<\/jats:bold>:<\/jats:styled-content> As a prelude to examining the functional roles of Slitrks, we identified eight <jats:italic>slitrk<\/jats:italic> orthologs in zebrafish and observed that seven of the eight orthologs were actively transcribed in the nervous system at embryonic, larval, and adult stages. Similar to previous findings in mice and humans, zebrafish <jats:italic>slitrks<\/jats:italic> exhibited unique but overlapping spatial and temporal expression patterns in the developing brain, retina, and spinal cord. <jats:styled-content><jats:bold>Conclusions:<\/jats:bold><\/jats:styled-content> Zebrafish express Slitrks in the developing central nervous system at times and locations important to neuronal morphogenesis and synaptogenesis. Future studies will use zebrafish as a convenient, cost\u2010effective model organism to characterize the functional roles of Slitrks in nervous system development. <jats:italic>Developmental Dynamics 243:339\u2013349, 2014<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24076","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T11:38:41Z","timestamp":1381577921000},"page":"339-349","source":"Crossref","is-referenced-by-count":9,"title":["Slitrk gene duplication and expression in the developing zebrafish nervous system"],"prefix":"10.1002","volume":"243","author":[{"given":"Jennifer","family":"Round","sequence":"first","affiliation":[{"name":"Department of Biology and Program in Neuroscience Davidson College Davidson North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Biology and Program in 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