{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:47:13Z","timestamp":1790167633347,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p><jats:styled-content>Background:<\/jats:styled-content> Tooth development is highly regulated in mammals and it is regulated by networks of signaling pathways (e. g. Tnf, Wnt, Shh, Fgf and Bmp) whose activities are controlled by the balance between ligands, activators, inhibitors and receptors. The members of the R\u2010spondin family are known as activators of Wnt signaling, and Lgr4, Lgr5, and Lgr6 have been identified as receptors for R\u2010spondins. The role of R\u2010spondin\/Lgr signaling in tooth development, however, remains unclear. <jats:styled-content>Results:<\/jats:styled-content> We first carried out comparative <jats:italic>in situ<\/jats:italic> hybridization analysis of <jats:italic>R\u2010spondins<\/jats:italic> and <jats:italic>Lgrs<\/jats:italic>, and identified their dynamic spatio\u2010temporal expression in murine odontogenesis. <jats:italic>R\u2010spondin2<\/jats:italic> expression was found both in tooth germs and the tooth\u2010less region, the diastema. We further examined tooth development in <jats:italic>R\u2010spondin2<\/jats:italic> mutant mice, and although molars and incisors exhibited no significant abnormalities, supernumerary teeth were observed in the diastema. <jats:styled-content>Conclusions:<\/jats:styled-content> R\u2010spondin\/Lgr signaling is thus involved in tooth development. <jats:italic>Developmental Dynamics 243:844\u2013851, 2014<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24124","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T06:22:34Z","timestamp":1394432554000},"page":"844-851","source":"Crossref","is-referenced-by-count":28,"title":["R\u2010spondins\/Lgrs expression in tooth development"],"prefix":"10.1002","volume":"243","author":[{"given":"Maiko","family":"kawasaki","sequence":"first","affiliation":[{"name":"Department of Craniofacial Development and Stem Cell Biology Dental Institute, King's College London, Guy's Hospital London Bridge London United Kingdom"},{"name":"Division of Bio\u2010Prosthodontics Department of Oral Health Science Course for Oral Life Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thantrira","family":"Porntaveetus","sequence":"additional","affiliation":[{"name":"Department of Craniofacial Development and Stem Cell Biology Dental Institute, King's College London, Guy's Hospital London Bridge London United Kingdom"},{"name":"Department of Physiology Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsushige","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Craniofacial Development and Stem Cell Biology Dental Institute, King's College London, Guy's Hospital London Bridge London United Kingdom"},{"name":"Department of Pedatric Dentistry Niigata University Graduate 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