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Transplantation studies in birds and amphibians demonstrate that when the otic placode is morphologically visible as a thickened patch of ectoderm, it is first committed to an otic fate. Fibroblast growth factor (FGF) signaling initiates induction of the otic placode, and levels of FGF signaling are fine\u2010tuned by the Sprouty family of antagonists of receptor tyrosine kinase signaling. <jats:bold><jats:styled-content>Results<\/jats:styled-content>:<\/jats:bold> Here, we examined the size of the otic placode and cup by combinatorial inactivation of the <jats:italic>Sprouty1<\/jats:italic> and <jats:italic>Sprouty2<\/jats:italic> genes. Interestingly, in a Sprouty gene dosage series, early enlargement of the otic placode was progressively restored to normal. Restoration of otic size was preceded by normal levels of FGF signaling, reduced cell proliferation and reduced cell death. <jats:bold><jats:styled-content>Conclusions<\/jats:styled-content>:<\/jats:bold> Our study demonstrates that excess otic placode cells, which form in response to increased FGF signaling, are not maintained in mammals. This suggests that growth plasticity exists in the mammalian otic placode and cup, and that FGF signaling may not be sufficient to induce the genetic program that maintains otic fate. <jats:italic>Developmental Dynamics 243:1317\u20131327, 2014<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24148","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T05:43:05Z","timestamp":1400737385000},"page":"1317-1327","source":"Crossref","is-referenced-by-count":8,"title":["Compensatory regulation of the size of the inner ear in response to excess induction of otic progenitors by fibroblast growth factor signaling"],"prefix":"10.1002","volume":"243","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Children's Research Institute, Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin 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