{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:56:37Z","timestamp":1783576597872,"version":"3.55.0"},"reference-count":66,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Deutsche Forg."},{"name":"FWO"},{"name":"IWT"},{"name":"KUL\/GOA"},{"name":"KUL\/OT"},{"name":"TREAT-OA 7th Framework program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p><jats:bold><jats:styled-content>Background<\/jats:styled-content><jats:styled-content>:<\/jats:styled-content><\/jats:bold> SMOC2 is a member of the BM\u201040 (SPARC) family of matricellular proteins, reported to influence signaling in the extracellular compartment. In mice, Smoc2 is expressed in many different tissues and was shown to enhance the response to angiogenic growth factors, mediate cell adhesion, keratinocyte migration, and metastasis. Additionally, <jats:italic>SMOC2<\/jats:italic> is associated with vitiligo and craniofacial and dental defects. The function of Smoc2 during early zebrafish development has not been determined to date. <jats:bold><jats:styled-content>Results:<\/jats:styled-content><\/jats:bold> In pregastrula zebrafish embryos, <jats:italic>smoc2<\/jats:italic> is expressed ubiquitously. As development progresses, the expression pattern becomes more anteriorly restricted. At the onset of blood cell circulation, <jats:italic>smoc2<\/jats:italic> morphants presented a mild ventralization of posterior structures. Molecular analysis of the <jats:italic>smoc2<\/jats:italic> morphants indicated myelopoietic defects in the rostral blood islands during segmentation stages. Hemangioblast development and further specification of the myeloid progenitor cells were shown to be impaired. Additional experiments indicated that Bmp target genes were down\u2010regulated in <jats:italic>smoc2<\/jats:italic> morphants. <jats:bold><jats:styled-content>Conclusions:<\/jats:styled-content><\/jats:bold> Our findings reveal that Smoc2 is an essential player in the development of myeloid cells of the anterior lateral plate mesoderm during embryonic zebrafish development. Furthermore, our data show that Smoc2 affects the transcription of Bmp target genes without affecting initial dorsoventral patterning or mesoderm development. <jats:italic>Developmental Dynamics 243:1375\u20131390, 2014<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24164","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T14:40:09Z","timestamp":1405435209000},"page":"1375-1390","source":"Crossref","is-referenced-by-count":24,"title":["Smoc2 modulates embryonic myelopoiesis during zebrafish development"],"prefix":"10.1002","volume":"243","author":[{"given":"Hendrik","family":"Mommaerts","sequence":"first","affiliation":[{"name":"Laboratory for Developmental and Stem Cell Biology Skeletal Biology and Engineering Research Center Department of Development and Regeneration KU Leuven \u2013 University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila 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