{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:11:20Z","timestamp":1762161080680,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T00:00:00Z","timestamp":1407974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE023337"],"award-info":[{"award-number":["DE023337"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE020855"],"award-info":[{"award-number":["DE020855"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p><jats:styled-content>Background:<\/jats:styled-content> Eph receptors, comprising the A\u2010 and B\u2010subfamilies, are the largest family of receptor tyrosine kinases in the mammalian genome, and their function is critical for morphogenesis in a variety of contexts. Whereas signaling through B\u2010type Ephs has been demonstrated to play a role in cleft lip and palate (CL\/P), the involvement of A\u2010type Ephs has not been examined in this context notwithstanding a recent genome\u2010wide association study that identified the <jats:italic>EPHA3<\/jats:italic> locus as a candidate for non\u2010syndromic CL\/P. <jats:styled-content>Results:<\/jats:styled-content> Here, we present a systematic analysis of the gene expression patterns for the nine EphA receptors at progressive stages of mouse development and find that <jats:italic>EphA3, EphA4<\/jats:italic>, and <jats:italic>EphA7<\/jats:italic> exhibit restricted overlapping patterns of expression during palate development. We find that homozygous mutation of <jats:italic>EphA3<\/jats:italic> or compound homozygous mutation of <jats:italic>EphA3<\/jats:italic> and <jats:italic>EphA4<\/jats:italic> in mice does not result in defective midfacial development, supporting the possibility of redundant function with <jats:italic>EphA7<\/jats:italic>. We also document previously undescribed expression patterns in other tissues of the craniofacial complex including the lacrimal duct and salivary glands. <jats:styled-content>Conclusions:<\/jats:styled-content> Together, these results are consistent with the hypothesis that mutations in <jats:italic>EPHA<\/jats:italic> family genes may cause CL\/P and also suggest that functional redundancy between family members may be at play. <jats:italic>Developmental Dynamics 243:1470\u20131476, 2014<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24170","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T12:32:19Z","timestamp":1406637139000},"page":"1470-1476","source":"Crossref","is-referenced-by-count":12,"title":["Embryonic expression of <i>EphA<\/i> receptor genes in mice supports their candidacy for involvement in cleft lip and palate"],"prefix":"10.1002","volume":"243","author":[{"given":"Puja","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Cell and Tissue Biology Program in Craniofacial and Mesenchymal Biology and Institute for Human Genetics, University of California San Francisco California"},{"name":"Department of Molecular and Cell Biology University of California Berkeley California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell and Tissue Biology Program in Craniofacial and Mesenchymal Biology and Institute for Human Genetics, University of California San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungil","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cell and Tissue Biology Program in Craniofacial and Mesenchymal Biology and Institute for Human Genetics, University of California San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ace E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Cell and Tissue Biology Program in Craniofacial and Mesenchymal Biology and Institute for Human Genetics, University of California San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey O.","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Cell and Tissue Biology Program in Craniofacial and Mesenchymal Biology and Institute for Human Genetics, University of California San Francisco 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