{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:24:44Z","timestamp":1791919484203,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["437003"],"award-info":[{"award-number":["437003"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["284522"],"award-info":[{"award-number":["284522"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["491229"],"award-info":[{"award-number":["491229"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p><jats:bold><jats:styled-content>Background:<\/jats:styled-content><\/jats:bold> The <jats:italic>YPEL<\/jats:italic> (<jats:italic>Yippee\u2010like<\/jats:italic>) gene family comprises five highly conserved members (<jats:italic>YPEL1\u20105<\/jats:italic>), but their biological function remains largely unknown. Early studies of <jats:italic>YPEL1<\/jats:italic> function suggested that it plays a role in the development of structures derived from the pharyngeal arches. Human <jats:italic>YPEL1<\/jats:italic> localises to distal chromosome 22q11.2 and copy number changes at this locus lead to diverse phenotypes that include facial dysmorphism, facial asymmetry, and palatal anomalies comprising the distal 22q11.2 deletion\/duplication syndromes (OMIM 611867). We therefore investigated the role of chick <jats:italic>YPEL1<\/jats:italic> in craniofacial development using ex vivo and in vivo approaches in the avian model. <jats:bold><jats:styled-content>Results:<\/jats:styled-content><\/jats:bold> We found that retroviral\u2010mediated in vivo overexpression of <jats:italic>YPEL1<\/jats:italic> causes abnormal mandibular morphogenesis associated with increased apoptosis and involvement of the <jats:italic>BMP<\/jats:italic>\/<jats:italic>MSX<\/jats:italic> pathway. <jats:bold><jats:styled-content>Conclusions:<\/jats:styled-content><\/jats:bold> Our results suggest that <jats:italic>YPEL1<\/jats:italic> expression is regulated by bone morphogenetic protein signaling and suggest a role for <jats:italic>YPEL1<\/jats:italic> in the pathogenesis of the craniofacial abnormalities observed in humans with distal chromosome 22q11.2 deletions or duplications. <jats:italic>Developmental Dynamics 244:1022\u20131030, 2015<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24299","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T09:19:58Z","timestamp":1433927998000},"page":"1022-1030","source":"Crossref","is-referenced-by-count":14,"title":["<i>YPEL1<\/i> overexpression in early avian craniofacial mesenchyme causes mandibular dysmorphogenesis by up\u2010regulating apoptosis"],"prefix":"10.1002","volume":"244","author":[{"given":"Tiong Yang","family":"Tan","sequence":"first","affiliation":[{"name":"Victorian Clinical Genetics Services, Royal Children's Hospital Melbourne Australia"},{"name":"Murdoch Children's Research Institute Melbourne Australia"},{"name":"Department of Paediatrics University of Melbourne Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Melbourne 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