{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:50:31Z","timestamp":1781743831276,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T00:00:00Z","timestamp":1449792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH","award":["EY08512, EY021784, EY023106"],"award-info":[{"award-number":["EY08512, EY021784, EY023106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p><jats:styled-content>Background:<\/jats:styled-content> We previously identified compound niches (CNs) at the limbal:corneal border of the mouse cornea that contain corneal epithelial progenitor cells, express Keratin 8 (K8), and goblet cell mucin Muc5AC. During re\u2010epithelialization after 2.5\u2009mm epithelial debridement wounds, CNs migrate onto the cornea and expand in number mimicking conjunctivalization. When CNs form during development and whether they express corneal epithelial progenitor cell enriched K14 was not known. <jats:styled-content>Results:<\/jats:styled-content> To provide insight into corneal epithelial homeostasis, we quantify changes in expression of simple (K8, K18, K19) and stratified squamous epithelial keratins (K5, K12, K14, and K15) during postnatal development and in response to 2.5\u2009mm wounds using quantitative polymerase chain reaction (Q\u2010PCR), confocal imaging and immunoblots. K14\u2009+\u2009CNs are present 7 days after birth. By 21 days, when the eyelids are open, K8, K19, and Muc5AC are also expressed in CNs. By 28 days after wounding, the corneal epithelium shows enhanced mRNA and protein expression for K14 and retains mRNA and protein for corneal epithelial specific K12. <jats:styled-content>Conclusions:<\/jats:styled-content> The keratin phenotype observed in corneal epithelial cells before eyelid opening is similar to that seen during wound healing. Data show K14\u2009+\u2009corneal epithelial progenitor cells expand in number after 2.5\u2009mm wounds. <jats:italic>Developmental Dynamics 245:132\u2013143, 2016<\/jats:italic>. \u00a9 2015 The Authors. Developmental Dynamics published by Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24365","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T20:10:52Z","timestamp":1446149452000},"page":"132-143","source":"Crossref","is-referenced-by-count":19,"title":["K14\u2009+\u2009Compound niches are present on the mouse cornea early after birth and expand after debridement wounds"],"prefix":"10.1002","volume":"245","author":[{"given":"Ahdeah","family":"Pajoohesh\u2010Ganji","sequence":"first","affiliation":[{"name":"Department of Anatomy and Regenerative Biology The George Washington University Medical School Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Pal\u2010Ghosh","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Regenerative Biology The George Washington University Medical School Washington 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