{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:48:26Z","timestamp":1790837306693,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH NIDCR","award":["R01 DE01870"],"award-info":[{"award-number":["R01 DE01870"]}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","award":["F31 DE020220"],"award-info":[{"award-number":["F31 DE020220"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>\n                    <jats:styled-content>Background:<\/jats:styled-content>\n                    Specification of cranial bone and dermal fibroblast progenitors in the supraorbital arch mesenchyme is Wnt\/\u03b2\u2010catenin signaling\u2010dependent. The mechanism underlying how these cells interpret instructive signaling cues and differentiate into these two lineages is unclear.\n                    <jats:italic>Twist1<\/jats:italic>\n                    is a target of the Wnt\/\u03b2\u2010catenin signaling pathway and is expressed in cranial bone and dermal lineages.\n                    <jats:styled-content>Results:<\/jats:styled-content>\n                    Here, we show that onset of\n                    <jats:italic>Twist1<\/jats:italic>\n                    expression in the mouse cranial mesenchyme is dependent on ectodermal Wnts and mesenchymal \u03b2\u2010catenin activity. Conditional deletion of\n                    <jats:italic>Twist1<\/jats:italic>\n                    in the supraorbital arch mesenchyme leads to cranial bone agenesis and hypoplastic dermis, as well as craniofacial malformation of eyes and palate.\n                    <jats:italic>Twist1<\/jats:italic>\n                    is preferentially required for cranial bone lineage commitment by maintaining Wnt responsiveness. In the conditional absence of\n                    <jats:italic>Twist1<\/jats:italic>\n                    , the cranial dermis fails to condense and expand apically leading to extensive cranial dermal hypoplasia with few and undifferentiated hair follicles.\n                    <jats:styled-content>Conclusions:<\/jats:styled-content>\n                    Thus,\n                    <jats:italic>Twist1<\/jats:italic>\n                    , a target of canonical Wnt\/\u03b2\u2010catenin signaling, also functions to maintain Wnt responsiveness and is a key effector for cranial bone fate selection and dermal condensation.\n                    <jats:italic>Developmental Dynamics 245:144\u2013156, 2016<\/jats:italic>\n                    . \u00a9 2015 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/dvdy.24367","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T11:11:36Z","timestamp":1450350696000},"page":"144-156","source":"Crossref","is-referenced-by-count":39,"title":["<i>Twist1<\/i>\n                    contributes to cranial bone initiation and dermal condensation by maintaining wnt signaling responsiveness"],"prefix":"10.1002","volume":"245","author":[{"given":"L. 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