{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:44:14Z","timestamp":1789937054181,"version":"4.0.1"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Scientific Foundation of China","award":["31071287"],"award-info":[{"award-number":["31071287"]}]},{"name":"Natural Scientific Foundation of China","award":["31371471"],"award-info":[{"award-number":["31371471"]}]},{"name":"Natural Scientific Foundation of China","award":["31201090"],"award-info":[{"award-number":["31201090"]}]},{"name":"Natural Scientific Foundation of Zhejiang","award":["LZ12C12002"],"award-info":[{"award-number":["LZ12C12002"]}]},{"name":"Natural Scientific Foundation of Zhejiang","award":["LY12C1200"],"award-info":[{"award-number":["LY12C1200"]}]},{"name":"Natural Scientific Foundation of Zhejiang","award":["NIH DE015654"],"award-info":[{"award-number":["NIH DE015654"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p><jats:styled-content>Background:<\/jats:styled-content> Mutations of <jats:italic>WNT3, WNT5A, WNT9B<\/jats:italic>, and <jats:italic>WNT11<\/jats:italic> genes are associated with orofacial birth defects, including nonsyndromic cleft lip with cleft palate in humans. However, the source of Wnt ligands and their signaling effects on the orofacial morphogenetic process remain elusive. <jats:styled-content>Results:<\/jats:styled-content> Using Foxg1\u2010Cre to impair Wnt secretion through the inactivation of Gpr177\/mWls, we investigate the relevant regulation of Wnt production and signaling in nasal\u2013facial development. Ectodermal ablation of Gpr177 leads to severe facial deformities resulting from dramatically reduced cell proliferation and increased cell death due to a combined loss of WNT, FGF and BMP signaling in the developing facial prominence. In the invaginating nasal pit, the Gpr177 disruption also causes a detrimental effect on migration of the olfactory epithelial cells into the mesenchymal region. The blockage of Wnt secretion apparently impairs the olfactory epithelial cells through modulation of JNK signaling. <jats:styled-content>Conclusions:<\/jats:styled-content> Our study thus suggests the head ectoderm, including the facial ectoderm and the neuroectoderm, as the source of canonical as well as noncanonical Wnt ligands during early development of the nasal\u2013facial prominence. Both \u03b2\u2010catenin\u2013dependent and \u2013independent signaling pathways are required for proper development of these morphogenetic processes. <jats:italic>Developmental Dynamics 245:414\u2013426, 2016<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24376","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T01:27:35Z","timestamp":1449710855000},"page":"414-426","source":"Crossref","is-referenced-by-count":24,"title":["Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP\/FGF\/JNK signaling axis"],"prefix":"10.1002","volume":"245","author":[{"given":"Xiao\u2010Jing","family":"Zhu","sequence":"first","affiliation":[{"name":"Institute of Developmental and Regenerative Biology, College of Life and Environmental Science Hangzhou Normal University Zhejiang 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