{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:33:11Z","timestamp":1784637191442,"version":"3.55.0"},"reference-count":124,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Thyroid C cells synthesize and secrete calcitonin, a serum calcium\u2010lowering hormone. This review provides our current understanding of mammalian thyroid C cells from the molecular and morphological perspectives. Several transcription factors and signaling molecules involved in the development of C cells have been identified, and genes expressed in the pharyngeal pouch endoderm, neural crest\u2010derived mesenchyme in the pharyngeal arches, and ultimobranchial body play critical roles for the development of C cells. It has been generally accepted, without much\u2010supporting evidence, that mammalian C cells, as well as the avian cells, are derived from the neural crest. However, by fate mapping of neural crest cells in both Wnt1\u2010Cre\/R26R and Connexin(Cxn)43\u2010lacZ transgenic mice, we showed that neural crest cells colonize neither the fourth pharyngeal pouch nor the ultimobranchial body. E\u2010cadherin, an epithelial cell marker, is expressed in thyroid C cells and their precursors, the fourth pharyngeal pouch and ultimobranchial body. Furthermore, E\u2010cadherin is colocalized with calcitonin in C cells. Recently, lineage tracing in Sox17\u20102A\u2010iCre\/R26R mice has clarified that the pharyngeal endoderm\u2010derived cells give rise to C cells. Together, these findings indicate that mouse thyroid C cells are endodermal in origin. <jats:italic>Developmental Dynamics 245:323\u2013341, 2016<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24377","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T11:10:17Z","timestamp":1449745817000},"page":"323-341","source":"Crossref","is-referenced-by-count":40,"title":["Cellular and molecular events on the development of mammalian thyroid C cells"],"prefix":"10.1002","volume":"245","author":[{"given":"Yoko","family":"Kameda","sequence":"first","affiliation":[{"name":"Department of Anatomy Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.40"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181ebd1a0"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02550"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0232"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02264"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00224943"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6606851"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80165-X"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016752"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)02150-0"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/350473a0"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-1042-z"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00866"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0028"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ssu.2980090503"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1005"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.9.1869"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63745-5"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20653"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl455"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.12.008"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00305120"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0283"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.059998"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00840.x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407577101"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10980"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2010.01.022"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.4.1357"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90381-Y"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161259898"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(19990201)254:2<269::AID-AR13>3.0.CO;2-G"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00357.x"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.24.3136"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.18.3913"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.8.1607"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.525"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126581"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2010.06.005"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290016"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.32.179"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.33.283"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.34.375"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.36.89"},{"key":"e_1_2_13_46_1","first-page":"97","article-title":"Distribution of C\u2010cells in parathyroid gland IV and thymus IV of different mammals studied by immunoperoxidase method using anti\u2010calcitonin and anti\u2010C\u2010thyroglobulin antisera","volume":"7","author":"Kameda Y","year":"1981","journal-title":"Kawasaki Med J"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.46.221"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-117-3-1239"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092190214"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001800107"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903590102"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-009-0760-7"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-1847-3"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233873"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092000409"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092040210"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092080111"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001820407"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0689"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0681-1"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540405200508"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21018"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.7A7179.2007"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.12.002"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21867"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.23819"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1649-z"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.1.60"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20655"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/27.5.445"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.113.4.1093"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511897948"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496718"},{"key":"e_1_2_13_74_1","first-page":"125","article-title":"Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos","volume":"34","author":"Li\u00e8vre CS","year":"1975","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh176"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00555654"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008279200"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1620"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.556"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.7.1989"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8827"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.08.030"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0598-87"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.12.009"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.10.032"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.10.027"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.038133"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20335"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.10.022"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00463"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416021-7.00004-3"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.054056"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.05.583"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-006-3439-7"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.4.1005"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320460608"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.08.048"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1662"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.03.008"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1177\/17.5.303"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.17.2735"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513819309048236"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-009-9613-0"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.4.612"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00306975"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/35039056"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.01.020"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2772"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.8.915"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.19.4605"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9219"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1204"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1969.tb00652.x"},{"key":"e_1_2_13_114_1","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1242\/dev.127.8.1553","article-title":"Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches","volume":"127","author":"Wendling O","year":"2000","journal-title":"Development"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21772"},{"key":"e_1_2_13_116_1","first-page":"1000129","article-title":"Misguided migration of C cell precursors to extra\u2010thyroidal locations related to defective pharyngeal pouch development in Shh deficient mice","volume":"4","author":"Westerlund J","year":"2013","journal-title":"Cell Dev Biol 2:issue"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03439-7"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-41-6-1076"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20484"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02018"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.13.3033"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1048903"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507961102"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9323"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gep.2013.07.001"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.24377","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.24377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T08:03:46Z","timestamp":1760342626000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.24377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,8]]},"references-count":124,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/dvdy.24377"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.24377","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,8]]}}}