{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:03:47Z","timestamp":1792782227831,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Agence National pour la Recherche","award":["ANR-07-MRAR-003"],"award-info":[{"award-number":["ANR-07-MRAR-003"]}]},{"name":"the FP7 Integrated Project CardioGeNet","award":["HEALTH-2007-B-223463"],"award-info":[{"award-number":["HEALTH-2007-B-223463"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:styled-content>Background:<\/jats:styled-content>\n                    <\/jats:bold>\n                    Coronary artery (CA) stems connect the ventricular coronary tree with the aorta. Defects in proximal CA patterning are a cause of sudden cardiac death. In mice lacking\n                    <jats:italic>Tbx1,<\/jats:italic>\n                    common arterial trunk is associated with an abnormal trajectory of the proximal left CA. Here we investigate CA stem development in wild\u2010type and\n                    <jats:italic>Tbx1<\/jats:italic>\n                    null embryos.\n                    <jats:bold>\n                      <jats:styled-content>Results:<\/jats:styled-content>\n                    <\/jats:bold>\n                    Genetic lineage tracing reveals that limited outgrowth of aortic endothelium contributes to proximal CA stems. Immunohistochemistry and fluorescent tracer injections identify a periarterial vascular plexus present at the onset of CA stem development. Transplantation experiments in avian embryos indicate that the periarterial plexus originates in mesenchyme distal to the outflow tract. Tbx1 is required for the patterning but not timing of CA stem development and a\n                    <jats:italic>Tbx1<\/jats:italic>\n                    reporter allele is expressed in myocardium adjacent to the left but not right CA stem. This expression domain is maintained in\n                    <jats:italic>\n                      Sema3c\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    hearts with a common arterial trunk and leftward positioned CA. Ectopic myocardial differentiation is observed on the left side of the\n                    <jats:italic>Tbx1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    common arterial trunk.\n                    <jats:bold>\n                      <jats:styled-content>Conclusions:<\/jats:styled-content>\n                    <\/jats:bold>\n                    A periarterial plexus bridges limited outgrowth of the aortic endothelium with the ventricular plexus during CA stem development. Molecular differences associated with left and right CA stems provide new insights into the etiology of CA patterning defects.\n                    <jats:italic>Developmental Dynamics 245:445\u2013459, 2016<\/jats:italic>\n                    . \u00a9 2015 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/dvdy.24380","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T03:38:40Z","timestamp":1451273920000},"page":"445-459","source":"Crossref","is-referenced-by-count":36,"title":["Coronary stem development in wild\u2010type and\n                    <i>Tbx1<\/i>\n                    null mouse hearts"],"prefix":"10.1002","volume":"245","author":[{"given":"Magali","family":"Th\u00e9veniau\u2010Ruissy","sequence":"first","affiliation":[{"name":"Aix\u2010Marseille University, CNRS, IBDM UMR 7288 Marseille 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