{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:12:23Z","timestamp":1791353543317,"version":"4.3.1"},"reference-count":123,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Helmholtz Association"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To fulfill their multiple roles in organ development and adult tissue homeostasis, hedgehog (HH) morphogens act through their receptor Patched (PTCH) on target cells. However, HH actions also require HH binding proteins, auxiliary cell surface receptors that agonize or antagonize morphogen signaling in a context\u2010dependent manner. Here, we discuss recent findings on the LDL receptor\u2010related protein 2 (LRP2), an exemplary HH binding protein that modulates sonic hedgehog activities in stem and progenitor cell niches in embryonic and adult tissues. LRP2 functions are crucial for developmental processes in a number of tissues, including the brain, the eye, and the heart, and defects in this receptor pathway are the cause of devastating congenital diseases in humans.\n                    <jats:italic>Developmental Dynamics 245:569\u2013579, 2016<\/jats:italic>\n                    . \u00a9 2016 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/dvdy.24394","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T09:49:48Z","timestamp":1455356988000},"page":"569-579","source":"Crossref","is-referenced-by-count":45,"title":["LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease"],"prefix":"10.1002","volume":"245","author":[{"given":"Annabel","family":"Christ","sequence":"first","affiliation":[{"name":"Max\u2010Delbrueck\u2010Center for Molecular Medicine 13125 Berlin 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