{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:37:47Z","timestamp":1790257067910,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T00:00:00Z","timestamp":1459814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NIDCR","award":["R01DE020884"],"award-info":[{"award-number":["R01DE020884"]}]},{"name":"NIH\/NIAAA","award":["U24AA014811"],"award-info":[{"award-number":["U24AA014811"]}]},{"name":"NIH\/NIAAA","award":["F31AA020731"],"award-info":[{"award-number":["F31AA020731"]}]},{"name":"NIH\/NIAAA","award":["F31GM73417-01"],"award-info":[{"award-number":["F31GM73417-01"]}]},{"name":"NIH\/NIAAA","award":["K99AA023560"],"award-info":[{"award-number":["K99AA023560"]}]},{"name":"the March of Dimes Birth Defects Foundation","award":["5-FY2003-132"],"award-info":[{"award-number":["5-FY2003-132"]}]},{"name":"The Chun Foundation"},{"name":"NIH\/NHLBI"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p><jats:bold><jats:styled-content>Background:<\/jats:styled-content><\/jats:bold> One of the most prevalent congenital birth defects is cleft palate. The palatal skeleton is derived from the cranial neural crest and platelet\u2010derived growth factors (Pdgf) are critical in palatogenesis. Of the two Pdgf receptors, <jats:italic>pdgfra<\/jats:italic> is required for neural crest migration and palatogenesis. However, the role <jats:italic>pdgfrb<\/jats:italic> plays in the neural crest, or whether <jats:italic>pdgfra<\/jats:italic> and <jats:italic>pdgfrb<\/jats:italic> interact during palatogenesis is unclear. <jats:bold><jats:styled-content>Results:<\/jats:styled-content><\/jats:bold> We find that <jats:italic>pdgfrb<\/jats:italic> is dispensable for craniofacial development in zebrafish. However, the palatal defect in <jats:italic>pdgfra;pdgfrb<\/jats:italic> double mutants is significantly more severe than in <jats:italic>pdgfra<\/jats:italic> single mutants. Data in mouse suggest this interaction is conserved and that neural crest requires both genes. In zebrafish, <jats:italic>pdgfra<\/jats:italic> and <jats:italic>pdgfrb<\/jats:italic> are both expressed by neural crest within the pharyngeal arches, and pharmacological analyses demonstrate Pdgf signaling is required at these times. While neither proliferation nor cell death appears affected, time\u2010lapsed confocal analysis of <jats:italic>pdgfra<\/jats:italic>;<jats:italic>pdgfrb<\/jats:italic> mutants shows a failure of proper neural crest condensation during palatogenesis. <jats:bold><jats:styled-content>Conclusions:<\/jats:styled-content><\/jats:bold> We provide data showing that <jats:italic>pdgfra<\/jats:italic> and <jats:italic>pdgfrb<\/jats:italic> interact during palatogenesis in both zebrafish and mouse. In zebrafish, this interaction affects proper condensation of maxillary neural crest cells, revealing a previously unknown interaction between Pdgfra and Pdgfrb during palate formation. <jats:italic>Developmental Dynamics 245:641\u2013652, 2016<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24403","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T02:27:46Z","timestamp":1457922466000},"page":"641-652","source":"Crossref","is-referenced-by-count":41,"title":["<i>Pdgfra<\/i> and <i>Pdgfrb<\/i> genetically interact during craniofacial development"],"prefix":"10.1002","volume":"245","author":[{"given":"Neil","family":"McCarthy","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, Institute for Neuroscience, Waggoner Center for Alcohol and Addiction Research University of Texas Austin Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn S.","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Research University of Hawaii Honolulu Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia M.","family":"Richarte","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Eskiocak","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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