{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:40:11Z","timestamp":1771260011920,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["Discovery Grant\u2014328376"],"award-info":[{"award-number":["Discovery Grant\u2014328376"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p><jats:styled-content><jats:bold>Background<\/jats:bold>:<\/jats:styled-content> The conjunctival papillae are epithelial thickenings of the conjunctiva that are required for the induction of underlying bones (the scleral ossicles). These transient papillae develop and become inductively active over an extended temporal period (HH 30\u201336, 6.5\u201310 dpf). While their inductive capacity was discovered in the mid\u20101900s, little is known about their development. <jats:bold><jats:styled-content>Results<\/jats:styled-content>:<\/jats:bold> Through a series of timed surgical ablations followed by in situ hybridization for <jats:italic>Bmp2<\/jats:italic>, we show that the ring of conjunctival papillae is not altered if the conjunctival epithelium is ablated either prior to or shortly after papillae induction (i.e., HH 29\u201330, 6.5\u20137 dpf). A conjunctival papilla ablated at or prior to HH 34 (8 dpf), when the complete ring is present, regenerates and quickly becomes inductively active, inducing an underlying scleral condensation with only a slight delay. This regenerative capacity extends until HH 35.5, a full 36 hours beyond the normal timeline of papillae induction. As such, the period of epithelial competency for papilla induction is longer than previously identified. <jats:bold><jats:styled-content>Conclusions<\/jats:styled-content>:<\/jats:bold> Papilla regeneration is a mechanism that ensures the formation of a complete sclerotic ring and provides another level of redundancy for the induction of a complete sclerotic ring during the normal inductive period. <jats:italic>Developmental Dynamics 246:381\u2013391, 2017<\/jats:italic>. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24489","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T17:58:33Z","timestamp":1486058313000},"page":"381-391","source":"Crossref","is-referenced-by-count":9,"title":["A wide temporal window for conjunctival papillae development ensures the formation of a complete sclerotic ring"],"prefix":"10.1002","volume":"246","author":[{"given":"Karyn","family":"Jourdeuil","sequence":"first","affiliation":[{"name":"Department of Medical Neuroscience Dalhousie University Halifax NS Canada"},{"name":"Department of Biology Mount Saint Vincent University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-2677","authenticated-orcid":false,"given":"Tamara Anne","family":"Franz\u2010Odendaal","sequence":"additional","affiliation":[{"name":"Department of Medical Neuroscience Dalhousie University Halifax NS Canada"},{"name":"Department of Biology Mount Saint Vincent University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2008.01014.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.74"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2010.01.007"},{"key":"e_1_2_7_5_1","first-page":"382","article-title":"The skeleton of the eye","volume":"5","author":"Coulombre AJ","year":"1962","journal-title":"I. Conjunctival papillae and scleral ossicles. 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