{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:47:57Z","timestamp":1790837277475,"version":"4.1.0"},"reference-count":161,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIDCR HD073107 (Cornell)"],"award-info":[{"award-number":["NIDCR HD073107 (Cornell)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIGMS PO1GM061354 (Liao)"],"award-info":[{"award-number":["NIGMS PO1GM061354 (Liao)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Zebrafish is a model organism that affords experimental advantages toward investigating the normal function of genes associated with congenital birth defects. Here we summarize zebrafish studies of genes implicated in orofacial cleft (OFC). The most common use of zebrafish in this context has been to explore the normal function an OFC\u2010associated gene product in craniofacial morphogenesis by inhibiting expression of its zebrafish ortholog. The most frequently deployed method has been to inject embryos with antisense morpholino oligonucleotides targeting the desired transcript. However, improvements in targeted mutagenesis strategies have led to widespread adoption of CRISPR\/Cas9 technology. A second application of zebrafish has been for functional assays of gene variants found in OFC patients; such in vivo assays are valuable because the success of in silico methods for testing allele severity has been mixed. Finally, zebrafish have been used to test the tissue specificity of enhancers that harbor single nucleotide polymorphisms associated with risk for OFC. We review examples of each of these approaches in the context of genes that are implicated in syndromic and non\u2010syndromic OFC. <jats:italic>Developmental Dynamics 246:897\u2013914, 2017<\/jats:italic>. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24566","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T04:32:41Z","timestamp":1502339561000},"page":"897-914","source":"Crossref","is-referenced-by-count":58,"title":["Zebrafish models of orofacial clefts"],"prefix":"10.1002","volume":"246","author":[{"given":"Kaylia M.","family":"Duncan","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Molecular and Cell Biology Graduate Program University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kusumika","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Division of Plastic and Reconstructive Surgery, 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