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The TGFB\u2010family protein Gsdf (gonadal soma derived factor) controls sex determination in some fish and is a candidate for mediating germ cell\/soma signaling. <jats:bold><jats:styled-content>Results:<\/jats:styled-content><\/jats:bold> Zebrafish expressed <jats:italic>gsdf<\/jats:italic> in somatic cells of bipotential gonads and expression continued in ovarian granulosa cells and testicular Sertoli cells. Homozygous <jats:italic>gsdf<\/jats:italic> knockout mutants delayed leaving the bipotential gonad state, but then became a male or a female. Mutant females ovulated a few oocytes, then became sterile, accumulating immature follicles. Female mutants stored excess lipid and down\u2010regulated <jats:italic>aromatase<\/jats:italic>, <jats:italic>gata4<\/jats:italic>, <jats:italic>insulin receptor<\/jats:italic>, <jats:italic>estrogen receptor<\/jats:italic>, and genes for lipid metabolism, vitellogenin, and steroid biosynthesis. Mutant females contained less estrogen and more androgen than wild\u2010types. Mutant males were fertile. Genomic analysis suggests that Gsdf, Bmp15, and Gdf9, originated as paralogs in vertebrate genome duplication events. <jats:bold><jats:styled-content>Conclusions:<\/jats:styled-content><\/jats:bold> In zebrafish, <jats:italic>gsdf<\/jats:italic> regulates ovarian follicle maturation and expression of genes for steroid biosynthesis, obesity, diabetes, and female fertility, leading to ovarian and extra\u2010ovarian phenotypes that mimic human polycystic ovarian syndrome (PCOS), suggesting a role for a related TGFB signaling molecule in the etiology of PCOS. <jats:italic>Developmental Dynamics 246:925\u2013945, 2017<\/jats:italic>. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24579","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T05:54:25Z","timestamp":1504158865000},"page":"925-945","source":"Crossref","is-referenced-by-count":95,"title":["Gonadal soma controls ovarian follicle proliferation through Gsdf in 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