{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:50:20Z","timestamp":1791640220399,"version":"4.3.4"},"reference-count":166,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS092705"],"award-info":[{"award-number":["R01NS092705"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children's","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    MicroRNAs are master regulators of gene expression. Single microRNAs influence multiple proteins within diverse molecular pathways and networks. Therefore, changes in levels or activity of microRNAs can have profound effects on cellular function. This makes dysregulated microRNA\u2010induced silencing an attractive potential disease mechanism in complex disorders like epilepsy, where numerous cellular pathways and processes are affected simultaneously. Indeed, several years of research in rodent models have provided strong evidence that acute or recurrent seizures change microRNA expression and function. Moreover, altered microRNA expression has been observed in brain and blood from patients with various epilepsy disorders, such as tuberous sclerosis. MicroRNAs can be easily manipulated using sense or antisense oligonucleotides, opening up opportunities for therapeutic intervention. Here, we summarize studies using these techniques to identify microRNAs that modulate seizure susceptibility, describe protein targets mediating some of these effects, and discuss cellular pathways, for example neuroinflammation, that are controlled by epilepsy\u2010associated microRNAs. We critically assess current gaps in knowledge regarding target\u2010 and cell\u2010specificity of microRNAs that have to be addressed before clinical application as therapeutic targets or biomarkers. The recent progress in understanding microRNA function in epilepsy has generated strong momentum to encourage in\u2010depth mechanistic studies to develop microRNA\u2010targeted therapies.\n                    <jats:italic>Developmental Dynamics 247:94\u2013110, 2018<\/jats:italic>\n                    . \u00a9 2017 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/dvdy.24582","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T11:12:44Z","timestamp":1504005164000},"page":"94-110","source":"Crossref","is-referenced-by-count":64,"title":["MicroRNA\u2010induced silencing in epilepsy: Opportunities and challenges for clinical application"],"prefix":"10.1002","volume":"247","author":[{"given":"Durgesh","family":"Tiwari","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Division of Neurology Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Peariso","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Division of Neurology Cincinnati Ohio"},{"name":"University of Cincinnati, Department of Pediatrics Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6057-2527","authenticated-orcid":false,"given":"Christina","family":"Gross","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Division of Neurology Cincinnati Ohio"},{"name":"University of Cincinnati, Department of Pediatrics Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527314666150317225945"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00466"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021396"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07122.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0013-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173060"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.783108"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01068.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-8-r90"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm995"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh415"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03059.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101823"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076051"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.05.012"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.02.042"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.50"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12711-016-0209-x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-94-017-8914-1_13","volume-title":"Issues in clinical epileptology: a view from the bench","author":"Buckmaster PS","year":"2014"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00129"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.10.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2016.0096"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2009.09.010"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002445"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7606"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002797"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4508"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.76"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.10.028"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.019"},{"key":"e_1_2_8_34_1","article-title":"CSF microRNA Profiling in Alzheimer's disease: a screening and validation study","author":"Dangla\u2010Valls A","year":"2016","journal-title":"Mol Neurobiol"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00140.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042316"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.07.019"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu276"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199746545.003.0031"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.12.009"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.08.049"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00040"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.172"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201487921"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04263"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030679"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09271"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq262"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3482"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.10.026"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh023"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.074"},{"key":"e_1_2_8_53_1","first-page":"1297","article-title":"Expression of p\u2010CREB and activity\u2010dependent miR\u2010132 in temporal lobe epilepsy","volume":"7","author":"Guo J","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815627882"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064023"},{"key":"e_1_2_8_56_1","first-page":"107385841770584","article-title":"The epigenetics of epilepsy and its progression","volume":"0","author":"Hauser RM","year":"2017","journal-title":"Neuroscientist"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.06.005"},{"key":"e_1_2_8_58_1","article-title":"Modulation of miR\u2010146a\/complement factor H\u2010mediated inflammatory responses in a rat model of temporal lobe epilepsy","volume":"36","author":"He F","year":"2016","journal-title":"Biosci Rep"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.010"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30246-0"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440609"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1371-16.2016"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00036"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-13-115"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.11.040"},{"key":"e_1_2_8_66_1","first-page":"1639","article-title":"MicroRNA\u2010132 silencing decreases the spontaneous recurrent seizures","volume":"7","author":"Huang Y","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2009.10.005"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.10.032"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18364"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.12.007"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01861.x"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044789"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.07.036"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0798-5"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2834"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3965"},{"key":"e_1_2_8_77_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1001\/jamapediatrics.2013.424","article-title":"Advanced treatments for childhood epilepsy: beyond antiseizure medications","volume":"167","author":"Joshi SM","year":"2013","journal-title":"JAMA Pediatr"},{"key":"e_1_2_8_78_1","first-page":"311","article-title":"MicroRNA dysregulation in multiple sclerosis","volume":"3","author":"Jr Ode F","year":"2013","journal-title":"Front Genet"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.141580"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12839"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2922-1"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100276"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32833749e4"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-015-0574-x"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2037"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1181"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1536"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-014-0368-6"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064921"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00018"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065062"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.01.005"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065329"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90529-Y"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.10.011"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.03.009"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11055-007-0036-1"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2010.02383.x"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815609148"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03315"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.186"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.05.016"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.039"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019077"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015691107"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.13.44"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2127"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01947-2"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22479"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.06.029"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.07.005"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.199828.115"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2446-16.2017"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw008"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20646"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03540.x"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.591420"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000225"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-9953-3"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2266"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr034"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02969-6"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.06.003"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.08.012"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15017798"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2016.11.002"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14143"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.246"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.23"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12448"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04367"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.02.073"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.10.023"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059011"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.07.003"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.09.016"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605298103"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244193"},{"key":"e_1_2_8_140_1","first-page":"6512620","article-title":"Intranasal delivery of miR\u2010146a mimics delayed seizure onset in the lithium\u2010pilocarpine mouse model","volume":"2017","author":"Tao H","year":"2017","journal-title":"Mediators Inflamm"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31826b3ab7"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3900-15.2016"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-016-0512-1"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060014"},{"key":"e_1_2_8_145_1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/glia.22983","article-title":"Expression of microRNAs miR21, miR146a, and miR155 in tuberous sclerosis complex cortical tubers and their regulation in human astrocytes and SEGA\u2010derived cell cultures","volume":"64","author":"Scheppingen J","year":"2016","journal-title":"Glia"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081774"},{"key":"e_1_2_8_147_1","article-title":"Immunity and inflammation in epilepsy","volume":"6","author":"Vezzani A","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.10.027"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv403"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508448102"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13348"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10201"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09522"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2016.3"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.04.049"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803072105"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90530-4"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.02.015"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw041"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0527"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.06.046"},{"key":"e_1_2_8_162_1","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.18632\/oncotarget.13744","article-title":"Altered microRNA profiles in plasma exosomes from mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"8","author":"Yan S","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5108489"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.08.005"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000610"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2015.02.001"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8981-5"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.24582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.24582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T17:13:30Z","timestamp":1760375610000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.24582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,4]]},"references-count":166,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/dvdy.24582"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.24582","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,4]]}}}