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In this review, we will discuss key points of Zebrafish ENS development, genes, and signaling pathways regulating ENS development, as well as contributions of the Zebrafish model system to better understand ENS disorders. During their migration, enteric progenitor cells (EPCs) display a gradient of developmental states based on their proliferative and migratory characteristics, and show spatiotemporal heterogeneity based on gene expression patterns. Many genes and signaling pathways that regulate the migration and proliferation of EPCs have been identified, but later stages of ENS development, especially steps of neuronal and glial differentiation, remain poorly understood. In recent years, Zebrafish have become increasingly important to test candidate genes for ENS disorders (e.g., from genome\u2010wide association studies), to identify environmental influences on ENS development (e.g., through large\u2010scale drug screens), and to investigate the role the gut microbiota play in ENS development and disease. With its unique advantages as a model organism, Zebrafish will continue to contribute to a better understanding of ENS development, function, and disease. <jats:italic>Developmental Dynamics 247:268\u2013278, 2018<\/jats:italic>. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24597","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T06:09:34Z","timestamp":1507097374000},"page":"268-278","source":"Crossref","is-referenced-by-count":66,"title":["Gut feelings: Studying enteric nervous system development, function, and disease in the zebrafish model system"],"prefix":"10.1002","volume":"247","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9471-1828","authenticated-orcid":false,"given":"Julia","family":"Ganz","sequence":"first","affiliation":[{"name":"Department of Integrative Biology Michigan State University East Lansing 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