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We report here the establishment of a transgenic mouse line that expresses Cre recombinase under the control of Six1\u201021, a major placodal enhancer of the homeobox gene <jats:italic>Six1<\/jats:italic>. <jats:styled-content><jats:bold>Results<\/jats:bold>:<\/jats:styled-content> In the new Cre\u2010expressing line, mSix1\u201021\u2010NLSCre, the earliest Cre\u2010mediated recombination was induced at embryonic day 8.5 in the region overlapping with the otic\u2010epibranchial progenitor domain (OEPD), a transient, common precursor domain for the otic and epibranchial placodes. Recombination was later observed in the OEPD\u2010derived structures (the entire inner ear and the VIIth\u2013Xth cranial sensory ganglia), olfactory epithelium, anterior pituitary, pharyngeal ectoderm and pouches. Other <jats:italic>Six1<\/jats:italic>\u2010positive structures, such as salivary\/lacrimal glands and limb buds, were also positive for recombination. Moreover, comparison with another mouse line expressing Cre under the control of the sensory neuron enhancer, Six1\u20108, indicated that the continuous and complex expression pattern of <jats:italic>Six1<\/jats:italic> during sensory organ formation is pieced together by separate enhancers. <jats:styled-content><jats:bold>Conclusions<\/jats:bold>:<\/jats:styled-content> mSix1\u201021\u2010NLSCre has several unique characteristics to make it suitable for analysis of cell lineage and gene function in sensory placodes as well as nonplacodal <jats:italic>Six1<\/jats:italic>\u2010positive structures. <jats:italic>Developmental Dynamics 247:250\u2013261, 2018<\/jats:italic>. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24603","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T01:39:37Z","timestamp":1509932377000},"page":"250-261","source":"Crossref","is-referenced-by-count":7,"title":["Regulation of continuous but complex expression pattern of <i>Six1<\/i> during early sensory development"],"prefix":"10.1002","volume":"247","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-2943","authenticated-orcid":false,"given":"Shigeru","family":"Sato","sequence":"first","affiliation":[{"name":"Division of Biology, Center for Molecular Medicine Jichi Medical University Shimotsuke Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhide","family":"Furuta","sequence":"additional","affiliation":[{"name":"Animal Resource Development Unit and Genetic Engineering Team, Division of Bio\u2010function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST) Kobe Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0058-4072","authenticated-orcid":false,"given":"Kiyoshi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Division of Biology, Center for Molecular Medicine Jichi Medical University Shimotsuke Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.devcel.2011.12.006","article-title":"Eya1\u2010Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2","volume":"22","author":"Ahmed M","year":"2012","journal-title":"Dev Cell"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1128\/MCB.01595-12","article-title":"Constitutively active ALK2 receptor mutants require type II receptor cooperation","volume":"33","author":"Bagarova J","year":"2013","journal-title":"Mol Cell Biol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2001.0156","article-title":"Vertebrate cranial placodes I","volume":"232","author":"Baker CV","year":"2001","journal-title":"Embryonic induction. 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