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Neuronal cell adhesion molecule (NrCAM) is a homophilic cell adhesion molecule that controls diverse aspects of nervous system development, but the function of NrCAM in cochlear development is not well understood. <jats:bold><jats:styled-content>Results<\/jats:styled-content><\/jats:bold>: Throughout cochlear innervation, NrCAM is detectable on spiral ganglion neuron (SGN) afferent and olivocochlear efferent fibers, and on the membranes of developing hair and supporting cells. Neonatal <jats:italic>Nrcam<\/jats:italic>\u2010null cochleae show errors in type II SGN fasciculation, reduced efferent innervation, and defects in the stereotyped packing of hair and supporting cells. <jats:italic>Nrcam<\/jats:italic> loss also leads to dramatic changes in the profiles of presynaptic afferent and efferent synaptic markers at the time of hearing onset. Despite these numerous developmental defects, <jats:italic>Nrcam\u2010<\/jats:italic>null adults do not show defects in auditory acuity, and by postnatal day 21, the developmental deficits in ribbon synapse distribution and sensory domain structure appear to have been corrected. <jats:bold><jats:styled-content>Conclusions<\/jats:styled-content><\/jats:bold>: NrCAM is expressed by several neural and sensory epithelial subtypes within the developing cochlea, and the loss of <jats:italic>Nrcam<\/jats:italic> confers numerous, but nonpermanent, developmental defects in innervation and sensory domain patterning. <jats:italic>Developmental Dynamics 247:934\u2013950, 2018<\/jats:italic>. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24629","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T07:50:11Z","timestamp":1521100211000},"page":"934-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Neuronal cell adhesion molecule (NrCAM) is expressed by sensory cells in the cochlea and is necessary for proper cochlear innervation and sensory domain patterning during development"],"prefix":"10.1002","volume":"247","author":[{"given":"Randall J.","family":"Harley","sequence":"first","affiliation":[{"name":"Department of Biology Georgetown University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Murdy","sequence":"additional","affiliation":[{"name":"Department of Biology Georgetown University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biology Georgetown University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa\u2010Jonne F.","family":"Ropp","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery The University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehoon H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biology Georgetown University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia F.","family":"Maness","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics The University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Manis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery and Department of Cell Biology and Physiology The University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2301-1151","authenticated-orcid":false,"given":"Thomas M.","family":"Coate","sequence":"additional","affiliation":[{"name":"Department of Biology Georgetown University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.071670"},{"key":"e_1_2_6_3_1","unstructured":"Allen Institute for Brain Science.2015.Allen Mouse Brain Atlas. 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