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Infiltration of activated lymphocytes and myeloid cells are thought to be primarily responsible for white matter damage and axonopathy. Several United States Food and Drug Administration\u2010approved therapies exist that impede activated lymphocytes from entering the CNS thereby limiting new lesion formation in patients with relapse\u2010remitting forms of MS. However, a significant challenge within the field of MS research is to develop effective and sustained therapies that allow for axonal protection and remyelination. In recent years, there has been increasing evidence that some kinds of stem cells and their derivatives seem to be able to mute neuroinflammation as well as promote remyelination and axonal integrity. Intracranial infection of mice with the neurotropic JHM strain of mouse hepatitis virus (JHMV) results in immune\u2010mediated demyelination and axonopathy, making this an excellent model to interrogate the therapeutic potential of stem cell derivatives in evoking remyelination. This review provides a succinct overview of our recent findings using intraspinal injection of mouse CNS neural progenitor cells and human neural precursors into JHMV\u2010infected mice. JHMV\u2010infected mice receiving these cells display extensive remyelination associated with axonal sparing. In addition, we discuss possible mechanisms associated with sustained clinical recovery. <jats:italic>Developmental Dynamics<\/jats:italic> 248:43\u201352, 2019. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.24658","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:05:04Z","timestamp":1533254704000},"page":"43-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Promoting remyelination through cell transplantation therapies in a model of viral\u2010induced neurodegenerative disease"],"prefix":"10.1002","volume":"248","author":[{"given":"Vrushali","family":"Mangale","sequence":"first","affiliation":[{"name":"Division of Microbiology &amp; Immunology, Department of Pathology University of Utah School of Medicine  Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura 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