{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:37:17Z","timestamp":1787747837496,"version":"build-2784847793"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004184","name":"Northeastern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004184","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Ambystoma mexicanum<\/jats:italic>, the axolotl salamander, is a classic model organism used to study vertebrate regeneration. It is assumed that axolotls regenerate most tissues, but the exploration of lung regeneration has not been performed until now.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unlike the blastema\u2010based response used during appendage regeneration, lung amputation led to organ\u2010wide proliferation. Pneumocytes and mesenchymal cells responded to injury by increased proliferation throughout the injured lung, which led to a recovery in lung mass and morphology by 56\u2009days post\u2010amputation. Receptors associated with the Neuregulin signaling pathway were upregulated at one and 3\u2009weeks post lung amputation. We show expression of the ligand, <jats:italic>neuregulin<\/jats:italic>, in the I\/X cranial nerve that innervates the lung and cells within the lung. Supplemental administration of Neuregulin peptide induced widespread proliferation in the lung similar to an injury response, suggesting that neuregulin signaling may play a significant role during lung regeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study characterizes axolotl lung regeneration. We show that the lung responds to injury by an organ\u2010wide proliferative response of multiple cell types, including pneumocytes, to recover lung mass.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dvdy.315","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T11:10:44Z","timestamp":1613387444000},"page":"866-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Lung injury in axolotl salamanders induces an organ\u2010wide proliferation response"],"prefix":"10.1002","volume":"250","author":[{"given":"Tyler B","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Biology Northeastern University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Giunta","sequence":"additional","affiliation":[{"name":"Department of Biology Northeastern University  Boston Massachusetts 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