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Glypicans, which are GPI (glycosylphosphatidylinositol)\u2010anchored proteins, and transmembrane\u2010anchored syndecans represent two major HSPG protein families whose involvement in development and disease has been demonstrated. Their participation in regenerative processes both of the central nervous system and of regenerating limbs is well documented. However, whether HSPG are expressed in regenerating zebrafish fins, is currently unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Here, we carried out a systematic screen of glypican and syndecan mRNA expression in regenerating zebrafish fins during the outgrowth phase. We find that 8 of the 10 zebrafish glypicans and the three known zebrafish syndecans show specific expression at 3\u2009days post amputation. Expression is found in different domains of the regenerate, including the distal and lateral basal layers of the wound epidermis, the distal most blastema and more proximal blastema regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HSPG expression is prevalent in regenerating zebrafish fins. Further research is needed to delineate the function of glypican and syndecan action during zebrafish fin regeneration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dvdy.321","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T23:24:10Z","timestamp":1614381850000},"page":"1368-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Heparan sulfate proteoglycan expression in the regenerating zebrafish fin"],"prefix":"10.1002","volume":"250","author":[{"given":"Sebastian","family":"Keil","sequence":"first","affiliation":[{"name":"Technische Universit\u00e4t Dresden CRTD \u2010 Center for Regenerative Therapies TU Dresden  Dresden Germany"},{"name":"Technische Universit\u00e4t Dresden Center for Healthy Aging TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Technische 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