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The primary clinical manifestation of FOP is extra\u2010skeletal bone formation (heterotopic ossification) within soft connective tissues. However, the underlying\n                    <jats:italic>ACVR1<\/jats:italic>\n                    mutation additionally alters skeletal bone development and nearly all people born with FOP have bilateral malformation of the great toes as well as other skeletal malformations at diverse anatomic sites. The specific mechanisms through which\n                    <jats:italic>ACVR1<\/jats:italic>\n                    mutations and altered BMP pathway signaling in FOP influence skeletal bone formation during development remain to be elucidated; however, recent investigations are providing a clearer understanding of the molecular and developmental processes associated with ACVR1\u2010regulated skeletal formation.\n                  <\/jats:p>","DOI":"10.1002\/dvdy.387","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T09:37:35Z","timestamp":1623836255000},"page":"144-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<scp>BMP<\/scp>\n                    signaling and skeletal development in fibrodysplasia ossificans progressiva (\n                    <scp>FOP<\/scp>\n                    )"],"prefix":"10.1002","volume":"251","author":[{"given":"Oscar 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