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Dental follicles are unique structures, considering that their remnants can persist within the jawbones after odontogenesis throughout life if the tooth does not erupt. Pathological changes may occur in these tissues as individuals age. The changes range from benign to life threatening. Thus, the assessment of age\u2010related changes in dental follicles associated with unerupted teeth is of paramount importance. In this review, we summarize the physiological roles and changes in dental follicles in odontogenesis, tooth eruption, and aging, in addition to the pathological changes associated with these structures. We encourage investigators to consider this peculiar tissue as a unique model and explore its potential to clarify its importance from the viewpoints of developmental biology, tissue physiology, and pathology.<\/jats:p>","DOI":"10.1002\/dvdy.406","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T11:01:16Z","timestamp":1627556476000},"page":"408-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Revisiting the human dental follicle: From tooth development to its association with unerupted or impacted teeth and pathological changes"],"prefix":"10.1002","volume":"251","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0360-4179","authenticated-orcid":false,"given":"Victor Coutinho","family":"Bastos","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Pathology, Faculty of Dentistry Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"},{"name":"Department of Pathology, Biological Sciences Institute Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-8009","authenticated-orcid":false,"given":"Ricardo Santiago","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, Faculty of Dentistry Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1580-4995","authenticated-orcid":false,"given":"Carolina Cavali\u00e9ri","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Sciences Institute Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374010150011001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"2015 A Balic I Thesleff Chapter seven \u2010 tissue interactions regulating tooth development and renewal 157 186","DOI":"10.1016\/bs.ctdb.2015.07.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12825"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.5.226"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512442896"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300103"},{"issue":"1","key":"e_1_2_9_8_1","first-page":"13","article-title":"The tooth as a model in organogenesis. 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