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Interestingly, cells within the basal corneal epithelium can regenerate new lenses in the frog, <jats:italic>Xenopus<\/jats:italic>. In this study, we investigated whether cornea sensory nerves or their neuropeptides are important for supporting cornea\u2010lens regeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Attempts to sever the trigeminal nerve trunk, which provides sensory nerve branches to the cornea, did not inhibit lens regeneration. However, using this approach we found that it was not possible to completely disrupt sensory innervation, as these nerves are able to quickly regenerate back to the cornea. On the other hand, attenuation of neuropeptide levels with capsaicin was found to significantly inhibit lens regeneration, as visualized by a reduction of Substance P. These treatments also led to a reduction of cornea sensory innervation. Interestingly, inhibition of the Substance P\u2010preferred receptor NK\u20101 with Spantide II did not affect lens\u2010regeneration rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides evidence that cornea nerves support cornea\u2010lens regeneration, which could occur through the release of various neurotrophic factors. Substance P, however, does not appear to be the critical component of this signaling pathway. Further studies are needed to investigate what role other known neurotrophic factors may play in this process.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dvdy.42","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T04:29:58Z","timestamp":1555475398000},"page":"530-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of sensory innervation in cornea\u2010lens regeneration"],"prefix":"10.1002","volume":"248","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-8090","authenticated-orcid":false,"given":"Kimberly J.","family":"Perry","sequence":"first","affiliation":[{"name":"University of Illinois Department of Cell and Developmental Biology  Urbana Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Illinois College Department of Biology  Jacksonville Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surabhi","family":"Sonam","sequence":"additional","affiliation":[{"name":"University of Illinois Department of Cell and Developmental Biology  Urbana Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratnakar","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Illinois Department of Comparative Biosciences  Urbana Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J.","family":"Henry","sequence":"additional","affiliation":[{"name":"University of Illinois Department of Cell and Developmental Biology  Urbana Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"461","article-title":"Sensory and sympathetic innervation of the mammalian cornea. 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