{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:29Z","timestamp":1786977509834,"version":"build-2736575974"},"reference-count":67,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001607","name":"Eye and Ear Foundation of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY08098"],"award-info":[{"award-number":["P30 EY08098"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R21\u2010EY25831"],"award-info":[{"award-number":["R21\u2010EY25831"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Mutations in\n                      <jats:italic>MAB21L2<\/jats:italic>\n                      result in severe ocular defects including microphthalmia, anophthalmia, coloboma, microcornea, and cataracts. The molecular and cellular underpinnings of these defects are unknown, as is the normal cellular function of MAB21L2. Zebrafish\n                      <jats:italic>mab21l2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>au10<\/jats:italic>\n                      <\/jats:sup>\n                      mutants possess ocular defects resembling those in humans with\n                      <jats:italic>MAB21L2<\/jats:italic>\n                      mutations, providing an excellent model to characterize mab21l2 functions during eye development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>mab21l2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mutants possessed a host of ocular defects including microphthalmia and colobomas as well as small, disorganized lenses and cornea dysgenesis. Decreased proliferation, increased cell death, and defects in marker gene expression were detected in the lens. Cell death in the optic stalk was elevated in\n                      <jats:italic>mab21l2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mutants and the basement membrane between the edges of the choroid fissure failed to break down. Neuronal differentiation in the retina was normal, however.\n                      <jats:italic>mab21l2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mutant corneas were disorganized, possessed an increased number of cells, some of which proliferated ectopically, and failed to differentiate the corneal stroma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>mab21l2 function is required for morphogenesis and cell survival in the lens and optic cup, and basement membrane breakdown in the choroid fissure. mab21l2 function also regulates proliferation in the lens and cornea; in its absence, the lens is small and mispatterned, and corneal morphogenesis and patterning are also disrupted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dvdy.44","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T22:36:11Z","timestamp":1556663771000},"page":"514-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Zebrafish\n                    <i>mab21l2<\/i>\n                    mutants possess severe defects in optic cup morphogenesis, lens and cornea development"],"prefix":"10.1002","volume":"248","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8962-5781","authenticated-orcid":false,"given":"Natalie","family":"Gath","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences Institute for Cellular and Molecular Biology, The University of Texas at Austin  Austin Texas"},{"name":"Departments of Ophthalmology and Developmental Biology, Louis J. Fox Center for Vision Restoration The University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9422-6312","authenticated-orcid":false,"given":"Jeffrey M.","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences Institute for Cellular and Molecular Biology, The University of Texas at Austin  Austin Texas"},{"name":"Departments of Ophthalmology and Developmental Biology, Louis J. Fox Center for Vision Restoration The University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.13.2397"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.07.016"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.05.005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24236"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.07.024"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22573"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2015.06.003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-5-48"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp854"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27498"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-384878-9.00007-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20919"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00074-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105358"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903440404"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21997"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2017.08.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1611"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(79)90164-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61760-X"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.025494"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2014.05.002"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.10.010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11061"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.23925"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.10.008"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108037"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.01.016"},{"key":"e_1_2_6_31_1","first-page":"1399","article-title":"Differential cataractogenic potency of TGF\u2010beta1, \u2212beta2, and \u2010beta3 and their expression in the postnatal rat eye","volume":"39","author":"Gordon\u2010Thomson C","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20282"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.12.2109"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.2.245"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/6844"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.23959"},{"key":"e_1_2_6_37_1","first-page":"2276","article-title":"Differential expression of aA\u2010 and aB\u2010crystallin during murine ocular development","volume":"37","author":"Robinson ML","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.11.3381"},{"key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1242\/dev.129.3.805","article-title":"Vax2 inactivation in mouse determines alteration of the eye dorsal\u2010ventral axis, misrouting of the optic fibres and eye coloboma","volume":"129","author":"Barbieri AM","year":"2002","journal-title":"Development"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.09.030"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.12.004"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.09.008"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.1.151"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1211"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.05.010"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.20.4325"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1276605"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02493"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.03.035"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds056"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt211"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.109.4.797"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1984.tb00266.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2009.05.009"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.09.003"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(89)90093-6"},{"key":"e_1_2_6_57_1","first-page":"2622","article-title":"The prenatal development of the optic fissure in colobomatous microphthalmia","volume":"32","author":"Hero I","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.05.577"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00042"},{"key":"e_1_2_6_60_1","first-page":"197","article-title":"Optic fissure closure in the normal cinnamon mouse. An ultrastructural study","volume":"31","author":"Hero I","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-0016-7.50046-1"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(78)90011-9"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.23.3764"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.9153"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2015.09.009"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.6.1337"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00399"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(94)90220-8"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.44","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.44","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dvdy.44","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.44","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T08:30:18Z","timestamp":1760344218000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,21]]},"references-count":67,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/dvdy.44"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.44","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,21]]},"assertion":[{"value":"2019-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}