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However, the exact mechanisms by which SHP2 regulates bone development remain unclear. This review focuses on the current understanding of the regulation of SHP2 and highlights the vital roles of SHP2 in skeletal development, especially its roles in ossification. Overall, a better understanding of the functions of SHP2 in ossification will provide a new avenue to treat\u2010related skeletal diseases.<\/jats:p>","DOI":"10.1002\/dvdy.449","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T08:58:18Z","timestamp":1640681898000},"page":"748-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of the protein tyrosine phosphatase <scp>SHP2<\/scp> in ossification"],"prefix":"10.1002","volume":"251","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-3378","authenticated-orcid":false,"given":"Yuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthodontics Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing  People's Republic of China"},{"name":"Nanjing Key Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing  People's Republic of 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