{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:38:35Z","timestamp":1790257115021,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007514","name":"Universit\u00e0 di Pisa","doi-asserted-by":"publisher","award":["219\u201060%2017 ORI"],"award-info":[{"award-number":["219\u201060%2017 ORI"]}],"id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The platelet\u2010derived growth factor (PDGF) family consists of four ligands (PDGF\u2010A, PDGF\u2010B, PDGF\u2010C, PDGF\u2010D) and two tyrosine kinase receptors (PDGFR\u2010\u03b1 and PDGFR\u2010\u03b2). In vertebrates, PDGF signaling influences cell proliferation, migration, and matrix deposition, and its up\u2010regulation is implicated in cancer progression. Despite this evidence, the role of each family member during embryogenesis is still incomplete and partially controversial. In particular, study of the role of pdgf signaling during craniofacial development has been focused on pdgf\u2010a, while the role of pdgf\u2010b is almost unknown due to the lethal phenotypes of pdgf\u2010b\u2010null mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By using a <jats:italic>pdgf\u2010b<\/jats:italic> splice\u2010blocking morpholino approach, we highlighted impairment of neural crest cell (NCC) migration in <jats:styled-content style=\"fixed-case\"><jats:italic>Xenopus laevis<\/jats:italic><\/jats:styled-content> morphants, leading to alteration of NCC derivatives formation, such as cranial nerves and cartilages. We also uncovered a possible link between pdgf\u2010b and the expression of cadherin superfamily members <jats:italic>cdh6<\/jats:italic> and <jats:italic>cdh11<\/jats:italic>, which mediate cell\u2010cell adhesion promoting NCC migration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggested that pdgf\u2010b signaling is involved in cranial NCC migration and it is required for proper formation of craniofacial NCC derivatives. Taken together, these data unveiled a new role for pdgf\u2010b during vertebrate development, contributing to complete the picture of pdgf signaling role in craniofacial development.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dvdy.47","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T13:14:30Z","timestamp":1557407670000},"page":"603-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["PDGF\u2010B: The missing piece in the mosaic of PDGF family role in craniofacial development"],"prefix":"10.1002","volume":"248","author":[{"given":"Debora","family":"Corsinovi","sequence":"first","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kety","family":"Giannetti","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Cericola","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Naef","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6777-0208","authenticated-orcid":false,"given":"Michela","family":"Ori","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"},{"name":"Inter\u2010University Center for the Promotion of the 3Rs Principles in Teaching &amp; Research (Centro 3R)  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.03.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.200493"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.288746.116"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00721"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1653708"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-11-97"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-013-9484-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.82"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011324"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.056903"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24403"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.147926"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.9.3099"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00241"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81270-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.16.1888"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152276"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1415"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.14.2691"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.16.1875"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.160045mo"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.23715"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.23107"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30302-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.01.021"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(87)90463-5"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr3005698"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.122"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.8501"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.09.056"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.519409"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085717"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.105551"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24517"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.23028"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.001115"},{"key":"e_1_2_6_38_1","volume-title":"Normal table of Xenopus laevis (Daudin): a systematical and chronological survey of the development from the fertilized egg till the end of metamorphosis","author":"Nieuwkoop PD","year":"1967"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(08)60307-6"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.041079"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.47","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.47","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dvdy.47","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.47","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T08:30:26Z","timestamp":1760344226000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/dvdy.47"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.47","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]},"assertion":[{"value":"2019-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}