{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:38:08Z","timestamp":1790797088515,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the cochlea, connexin 26 (Cx26) and connexin 30 (Cx30) co\u2010assemble into two types of homomeric and heteromeric gap junctions between adjacent non\u2010sensory epithelial cells. These channels provide a mechanical coupling between connected cells, and their activity is critical to maintain cochlear homeostasis. Many of the mutations in <jats:italic>GJB2<\/jats:italic> or <jats:italic>GJB6<\/jats:italic>, which encode Cx26 and Cx30 in humans, impair the formation of membrane channels and cause autosomal syndromic and non\u2010syndromic hearing loss. Thus, deciphering the connexin trafficking pathways in situ should represent a major step forward in understanding the pathogenic significance of many of these mutations. A growing body of evidence now suggests that Cx26\/Cx30 heteromeric and Cx30 homomeric channels display distinct assembly mechanisms. Here, we review the most recent advances that have been made toward unraveling the biogenesis and stability of these gap junctions in the cochlea.<\/jats:p>","DOI":"10.1002\/dvdy.538","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T08:40:17Z","timestamp":1663231217000},"page":"239-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Recent insights into gap junction biogenesis in the cochlea"],"prefix":"10.1002","volume":"252","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9546-5091","authenticated-orcid":false,"given":"Jean","family":"Defourny","sequence":"first","affiliation":[{"name":"GIGA\u2010Neurosciences, Unit of Cell and Tissue Biology University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Thiry","sequence":"additional","affiliation":[{"name":"GIGA\u2010Neurosciences, Unit of Cell and Tissue Biology University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.94"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012052"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/12612"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/387080a0"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2012.06.024"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165\u20100173(99)00076\u20104"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00018.2009"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1205"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004088"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.125476"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010014\u20102029\u2010z"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00341.2004"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u2010291X(03)01166\u20105"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010015\u20102113\u2010z"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00011.2007"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304\u20103940(00)01626\u20108"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002320001051"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240000355"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.112.4.447"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232001\u20100014\u20104"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162055899"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(93)90728\u20109"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2013.07.006"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00038.2012"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E10\u201006\u20100548"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.138230"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.02.008"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800831105"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102230.2005.01878.x"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2011.07900.x"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.08.152"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/cac.10.4\u20106.341.346"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg076"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.10.005"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.50"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.01.010"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67621"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.09.023"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi1004156"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107007\u20107\u201052"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.01.020"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.108137"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3254"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2018.05.002"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E16\u201010\u20100697"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34586"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2011.07.001"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/35041037"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.037"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02903"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi050495a"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068793"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2019681118"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2018.10.001"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13234"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2019.02.004"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00516.2010"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040315"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/21907"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8017"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07\u201006\u20100596"},{"key":"e_1_2_4_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0121656"},{"key":"e_1_2_4_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2021.06.008"},{"key":"e_1_2_4_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010020\u20100377\u20101"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.174698"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2009.03.001"},{"key":"e_1_2_4_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.659979"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02569"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dvdy.538","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:52:15Z","timestamp":1760370735000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,26]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/dvdy.538"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.538","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,26]]},"assertion":[{"value":"2022-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}