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The leading DS candidate gene is trisomy of the Down syndrome cell adhesion molecule (DSCAM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We find that Dscam1 protein is expressed in the <jats:italic>Drosophila<\/jats:italic> enteric\/stomatogastric nervous system (SNS). Axonal <jats:italic>Dscam1<\/jats:italic> phenotypes can be rescued equally by diverse isoforms. Overexpression of <jats:italic>Dscam1<\/jats:italic> resulted in frontal and hindgut nerve overgrowth. Expression of dominant negative <jats:italic>Dscam1\u2010\u0394C<\/jats:italic> led to a truncated frontal nerve and increased branching of the hindgut nerve. Larval locomotion is influenced by feeding state, and we found that the average speed of larvae with <jats:italic>Dscam1<\/jats:italic> SNS expression was reduced, whereas overexpression of <jats:italic>Dscam1\u2010\u0394C<\/jats:italic> significantly increased the speed. <jats:italic>Dscam1<\/jats:italic> overexpression reduced the efficiency of food clearance from the larval gut.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our work demonstrates that overexpression of Dscam1 can perturb gut function in a model system.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dvdy.554","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T13:49:41Z","timestamp":1669902581000},"page":"156-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Dscam1<\/i> overexpression impairs the function of the gut nervous system in 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