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This transition involves the refinement of expression of genes that are first found broadly throughout the heart tube and then become restricted to the AVC. Despite the importance of cardiac patterning, we do not fully understand the mechanisms that limit gene expression to the AVC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We show that the zebrafish gene <jats:italic>smarcc1a<\/jats:italic>, encoding a BAF chromatin remodeling complex subunit homologous to mammalian BAF155, is critical for cardiac patterning. In <jats:italic>smarcc1a<\/jats:italic> mutants, myocardial differentiation and heart tube assembly appear to proceed normally. Subsequently, the <jats:italic>smarcc1a<\/jats:italic> mutant heart fails to exhibit refinement of gene expression patterns to the AVC, and the persistence of broad gene expression is accompanied by failure of chamber expansion. In addition to their cardiac defects, <jats:italic>smarcc1a<\/jats:italic> mutants lack pectoral fins, indicating similarity to <jats:italic>tbx5a<\/jats:italic> mutants. However, comparison of <jats:italic>smarcc1a<\/jats:italic> and <jats:italic>tbx5a<\/jats:italic> mutants suggests that perturbation of <jats:italic>tbx5a<\/jats:italic> function is not sufficient to cause the <jats:italic>smarcc1a<\/jats:italic> mutant phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data indicate an important role for Smarcc1a<jats:italic>\u2010<\/jats:italic>containing chromatin remodeling complexes in regulating the changes in gene expression and morphology that distinguish the AVC from the cardiac chambers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dvdy.595","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T06:44:33Z","timestamp":1682059473000},"page":"157-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Zebrafish <i>smarcc1a<\/i> mutants reveal requirements for BAF chromatin remodeling complexes in distinguishing the atrioventricular canal from the cardiac chambers"],"prefix":"10.1002","volume":"253","author":[{"given":"Heidi J.","family":"Auman","sequence":"first","affiliation":[{"name":"Skirball Institute New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivy H.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of California  San Diego, La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar A.","family":"Berr\u00edos\u2010Otero","sequence":"additional","affiliation":[{"name":"Skirball Institute New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Colombo","sequence":"additional","affiliation":[{"name":"Skirball Institute New York University School of Medicine  New York New York 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