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In humans, mutations in\n                      <jats:italic>Pss<\/jats:italic>\n                      lead to Lenz\u2013Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of\n                      <jats:italic>Pss<\/jats:italic>\n                      mutations on the growth of\n                      <jats:italic>Drosophila melanogaster<\/jats:italic>\n                      are not fully known. Hence, this study was conducted to investigate the effects of\n                      <jats:italic>Pss<\/jats:italic>\n                      knockdown on the growth and development of\n                      <jats:italic>D<\/jats:italic>\n                      .\n                      <jats:italic>melanogaster<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Enterocyte (EC)\u2010specific\n                      <jats:italic>Pss<\/jats:italic>\n                      knockdown resulted in reduced cell size in the gut via reduced Akt signaling. EC\u2010specific\n                      <jats:italic>Pss<\/jats:italic>\n                      knockdown was associated with a decrease in gut size, a change in gut pH, and reduced food intake. These abnormalities affected normal nutrient metabolism in larvae, leading to decreased secretion of\n                      <jats:italic>Drosophila<\/jats:italic>\n                      insulin\u2010like peptides. Consequently, the reduced systemic Akt signaling at the organismal level resulted not only in impaired gut growth but also in abnormal organismal growth and development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings highlight the significant role of the\n                      <jats:italic>Pss<\/jats:italic>\n                      gene in the growth and development of\n                      <jats:italic>D<\/jats:italic>\n                      .\n                      <jats:italic>melanogaster<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  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